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Some of the questions that remain unanswered

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Vaccines that make use of the entire pathogenic virus are called whole virus vaccines. Using a pathogen or a part of a pathogen in a vaccine is a traditional approach, and most vaccines available today work this way.

In contrast, the COVID-19 mRNA vaccines by Pfizer-BioNTech and Moderna use genetic material that is chemically synthesized in a laboratory to teach our immune system how to fight off future infections with the SARS-CoV-2 virus.

Date:   9/12/2021 11:53:15 AM   ( 78 d ) ... viewed 219 times

Controversies around vaccine boosters

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Until scientists collect and publish the results from these studies, whether booster vaccine doses are truly helpful in the fight against COVID-19 remains an open question. For now, experts recommend taking a full course of whatever COVID-19 vaccine is available in a person’s country.

“We have learned a great deal about COVID vaccines in a very short time, but there’s still plenty we don’t know yet,” Dr. Justman told MNT.

Some of the questions that remain unanswered, she noted, include:

“Is it better to boost with the same vaccine (a homologous boost) that was initially given or with a different vaccine (a heterologous boost)?

What is the best method to measure the different components of the immune response after vaccination?

For those who take immunosuppressive medications, would a brief reduction in these medications be better than or just as good as a booster?

What dose should a booster be, and at what time interval?

Is a booster safe in all age groups?

[Are there] any groups who may not do well with a booster?

What age group would benefit most from a booster?”

These are all questions that researchers are doing their best to address as soon as possible. This does not change the fact, said Dr. Justman, that: “[t]he most important booster is to vaccinate as many people as possible right now, both here in the U.S. and globally.”

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