Cancer-Killing Effect Of High Oral-D... 
chrisb1
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Clarkia Tincture 2 oz, 4 oz, 8 oz, and 16 oz
In an overlooked study first published in 2008, for the first time, using a special liposomal form of oral-dose vitamin C, researchers in Britain demonstrated it is possible to achieve cancer-killing blood concentrations of this vitamin without undesirable side effects.
Heretofore, National Institutes of Health Researchers claimed the maximal concentration of vitamin C that can be achieved following oral intake is not sufficient to produce a cancer-killing effect. Now British researchers demonstrate they were able to achieve blood concentrations of vitamin C that were twice what was incorrectly reported to be maximal, and in the range of what is known to be selectively toxic to tumor cells, yet not harmful to healthy cells.
Studies with various forms of cancer show a 30-to-50 percent cancer cell-killing effect at the same blood concentration of vitamin C achieved in this study. For comparison, anti-cancer drugs are approved by the FDA if they achieve 50 percent tumor shrinkage.
Researchers Stephen Hickey and Hilary J. Roberts, long-time advocates of vitamin C therapy and authors of the book Ascorbate: The Science of Vitamin C, writing in the Journal of Nutritional & Environmental Medicine, believe even higher concentration of vitamin C can be achieved, up to three times what was once mistakenly believed to be maximal, with measured, repeated oral doses.
It was Linus Pauling, the two-time Nobel Prize winner, who first employed intravenous vitamin C to prolong the lives of terminal cancer patients. This was reported in 1978.
A year later Mayo Clinic researchers then followed with a study of their own, which utilized oral-dose vitamin C, and errantly dispelled the notion of using vitamin C to treat cancer. However, oral doses cannot achieve the same high blood concentration that intravenous vitamin C can produce.
Only recently has it come to light that the dismissal of vitamin C for cancer therapy was based upon oral-dose vitamin C, and subsequent studies found intravenous vitamin C has the potential to be used in cancer therapy. Some small pilot studies appear to be encouraging with the use of intravenous vitamin C therapy. Cancer researchers have recently called for a reconsideration of intravenous vitamin C therapy.
According to researchers Hickey and Roberts, repeated doses, and use of a special liposomal form of vitamin C that is absorbed in the gut and then into the liver before it is released into the blood stream, are key to making oral vitamin C therapy effective. Another important factor is to limit the consumption of carbohydrates (refined sugar) which impairs oral absorption of this vitamin.
Dr. John Ely, emeritus professor at the University of Washington, has also shown that Sugar depletes vitamin C from white blood cells and makes them sluggish. White blood cells are the very cells that attack tumor cells and destroy them.
The liposomal form of vitamin C employed in this study consists of 1-gram (1000 milligram) dose sachets of vitamin C powder encapsulated in lecithin (phosphatidylcholine), as supplied by Livon Laboratories of Henderson, Nevada.
A British laboratory (Biolab, London) that has conducted thousands of vitamin C assays over a 10-year period, confirms that 20-gram and 36-gram doses of oral vitamin C, as utilized by researchers Hickey and Roberts, achieved far higher blood concentration than had ever been measured previously. Repeated dosing rather than massive single-dose vitamin C averts side effects such as diarrhea.
The cancer cell-killing effect of vitamin C is realized by the transient production of hydrogen peroxide (H2O2) within connective tissues (not in blood), which then destroys tumor cells, and subsequently turns to harmless water (H2O), ensuring non-toxic therapy.
Reluctance by modern medical practitioners to offer vitamin C therapy to their cancer patients suggests the public will have to practice vitamin C therapy at home. This need not be a totally unguided experience, as there are instructive books available. Why this landmark study has been completely overlooked by the cancer community goes unexplained. The study was published in a journal catalogued by the National Library of Medicine (NLM), but articles from that journal cannot be accessed at the NLM website. When this report was submitted for publication, the publisher of the journal suddenly changed editors and the new editor attempted to scratch the report from its publication schedule altogether. Finally the report did get published, but suddenly the journal itself was discontinued and its articles no longer indexed by NLM. It appears an intentional effort was made to bury this study. An online abstract is provided at the Journal of Nutritional and Environmental Medicine website.
Dr. Cinque's comments: I have said before that I would not want to undergo high-dose Vitamin C therapy all the time. However, my mind is entirely open to the possibility that it could be useful in treatment and management of cancer. Keep in mind that we are not talking about a nutritional effect here. It is most definitely a matter of poisoning. However, compared to chemotherapy, it is extremely safe and pretty close to harmless. And even in terminal cancer cases, it might bide the individvual much precious time.
Liposomal Encapsulation Technology has been around since the 1970s, but it is just now finding practical application. The idea is to provide nutrients in a form that resists degradation in the gut, for instance by wrapping it in a phospholipid such as lecithin, which leading to more efficient absorption and utilization. For instance, VRP has begun offering Liposomal Glutathione as a way to get around the digestive cleavage of the peptide bonds in the gut. This is major breakthrough, and it makes all other forms of glutathione obsolete.................
http://www.1to1vitamins.com/news/2010/artl7947.html
Chrisb1.
- Re: Cancer-Killing Effect Of High Or... InCharge
14 y
35,906
MoreThis is a reply to # 1,556,665
This is interesting, and believable.
"The study was published in a journal catalogued by the National Library of Medicine (NLM), but articles from that journal cannot be accessed at the NLM website. When this report was submitted for publication, the publisher of the journal suddenly changed editors and the new editor attempted to scratch the report from its publication schedule altogether. Finally the report did get published, but suddenly the journal itself was discontinued and its articles no longer indexed by NLM. It appears an intentional effort was made to bury this study. An online abstract is provided at the Journal of Nutritional and Environmental Medicine website."
- Homemade (With ultrasound) Liposomal... ladylove
14 y
53,276
This is a reply to # 1,556,755Also posted on the "Ask Trapper" forum, but apparently can't cross-post from there- LL
From:
//www.curezone.org/forums/fm.asp?i=1554526#i
Hello Forumfolk,
I think this is information is of interest to probably every human being on the planet.
Good Health to All of Us,
Ladylove :)
-------------------------------------------------
From:
http://pdazzler.com/2009/08/11/make-your-own-liposomal-encapsulated-vitamin-c/
Make Your Own Liposomal Encapsulated Vitamin C
From: Brooks Bradley
Sent: Tuesday, August 11, 2009 12:20 PM
To:
Subject: CS>Liposomal Encapsulation Technology: Vit “C”
In our recent researches evaluating this technology and, consequently, in searching for possible “process” improvements/modifications which might facilitate the “lay person” an opportunity for a DIY methodology achievable in a home environment—we did achieve some notable progress.
First, a brief summary of our exploratory activity. Our literature searches revealed several companies actively exhibiting valid capability in this area (LET).
Typical, and demonstrably capable, is a company named MICROTEK. Microteklabs.com
Helpful information is available here.
One fact became obvious, early on, to wit: The truly striking feature of LET was a NATURALLY-occurring characteristic…… and not a man-made process, that was driving this encapsulation process. That is, this process is a function of an automatic, “natural tendency” of certain substances (e.g. phospholipids in this case) to form tiny vacoules or
bubbles—called liposomes—-when in a aqueous solution under certain conditions. ”
The keystone activity is that these liposomes automatically fill themselves with whatever aqueous solution they were in—-before they were formed. “This type of bubble, called a membrane, forms a protective barrier around virtually every cell in the human body.”
Livon Labs has perfected a process which employs a high-pressure (1700 p.s.i.) discharge system which directs a liquid stream against a forming plate. The high impact forces the phospholipids (soy lecithin in this case) to form liposomes—-so small they require an electrom microscope for viewing. This technology does not create the LET activity….it just enhances it. In our personal researches we have determined the key to exploiting the LET phenomenon appeared to be Livon’s application of intense force in their mixing methodology.
Enter the “enlightening” moment. Searching for a method of achieving liposomal encapsulation, it occurred to us to explore ultrasonic stimulation as an option. It worked…maybe not quite as well as Livon’s “high tech” brute force approach…but about 70% as well. Plenty efficient for our purposes.
Our vitamin “C” liposomal encapsulation protocol is as follows:
Using a small (2 cup) Ultrasonic cleaner, (Item #03305, obtainable from Harbor Freight @ about $30.00), we performed the following:
1. Dissolved 3 level tablespoons of soy lecithin in 1 cup of water (preferably distilled). Note: This is key to being successful from the start. Mix the lecithin and distilled water in a seal-able quart jar so you can shake/agitate until the lecithin is completely dissolved. You don’t want any lecithin granules visible. Keep agitating until all granules are dissolved.
2. Dissolved 1 level tablespoon of ascorbic acid powder (Vit. “C”) in 1/2 cup of water.
3. Poured both solutions together in the ultrasonic cleaner bowl and turned the unit on. Using a plastic straw (leaving the top of the cleaner opened), gently, slowly, stirred the contents. Note: The cleaner will, automatically, self-stop about every 2 minutes. Just push ON button to continue. Repeat for a total of 3 series (6 minutes). By that time the entire solution should be blended into a cloudy, homogeneous, milk-like mixture. The LET solution is now formed. Tip: Pour the dissolved Vitamin C solution into the seal-able quart jar with the dissolved lecithin and shake briefly prior to pouring into the ultra-sonic cleaner. If you dissolved your lecithin first as directed in the note above you will need to close the lid due to bubbling. Simply open the lid frequently and give the mixture a quick stir before closing the lid again.
4. This protocol furnishes about 12 grams (12000mg.) of vitamin C product. At 70% encapsulation efficiency, 8400 mg would be of the LET type. This solution will keep, acceptably, at room temperature for 3 to 4 days. Refrigerated, it will keep much longer.
Note: You can use the verification test described in comment #3 below to test the efficacy of your Liposomal Vitamin C. If you followed the tip about completely dissolving the lecithin granules prior to mixing in the ultrasonic cleaner you should have 75%+ encapsulation.
We use it so fast around our place…there isn’t enough left to be concerned over storage. The “homogenizing effect” is so powerful that after 3 days at room temperature, no precipitation or solution separation appears evident. This type of sequestered vitamin “C” has demonstrated to be, at least 5 times more effective (per volumetric measure) than any other form of orally-ingested vitamin “c”….that we have tested.
Additionally, it appears to be even more rapid in tissue-bed availability—-than IV applications. An astounding revelation….to us. We estimate the DIY researcher can produce the active LET portion of this solution for 15 cents per gram….as against about $1.00 per gram from commerci! al sources.
It is my hope that this, limited, explanation of our activities in this area,
is of some value to our do-it-yourself health-maintenance researchers. In any event, this protocol has demonstrated to be non-toxic and most helpful to OUR RESEARCHERS.
Sincerely, Brooks Bradley.
p.s. A larger, more powerful, ultrasonic cleaner is now available at Harbor Freight. Item number 91593. 2+ liters, for about $60.00. Both units have performed quite well for us. Almost as well as our $500.00 lead zirconate titanate, research grade, unit.
Hi all…After my first batch of LC sat in the fridge over night it separated…wondering if anyone could explain why or what I might have done wrong? Brooks said it would not separate….hum?Best regards…Sandy
Dear Sandy,My apologies; I neglected to outline the attendant, probable, variations in the protocol. What I SHOULD have said in my original post is “The visible, obviously homogenized, portion of the solution”, whenever I made the comment about the stability of the completed, resultant, material.I believe you will gain a little better knowledge of the results you achieved, after reading my most recent comment on an inquiry by Sheila.
Bottom line -your result was perfectly normal. Interestingly, the meniscus may present at the top…or the bottom…..or not at all. Usually if the initial material combination has not run long enough to incorporate a majority of the lecithin (or there is simply too much lecithin for the available ascorbic acid fraction…..the meniscus will form on the top of the sample within a few minutes after stopping the US agitation.
If your procedure has run acceptably well and-long enough to homogenize well, any meniscus formation will, generally, present on the BOTTOM after overnight storage with or without refrigeration.
In any event, you are doing fine. If you do not want to consume the isolated lecithin fraction you are observing, just decant the homogenized liposome solution and dispose of the isolated lecithin fraction.
I hope this information helps your dilemma.
Sincerely, Brooks Bradley.
p.s. One just needs to continue to experiment “around-the-edges” of this protocol, in order to achieve optimum results. Do not be reluctant to do such this IS NOT ROCKET Science …just common sense.
Dear Sheila,
Your question has been asked by others….(private inquires addressed directly to me). In the interest of saving me time and energy, I offer the following explanation.
First, soy lecithin is a slow incorporator, when introduced into aqueous mediums….sometimes. Especially, when there is a high lecithin granule population ratio-relative to the total water volume. The general reaction is that a major percentage of the lecithin blends readily with the the water medium, but there will remain a definitive lecithin component which floats on the surface and exhibits a somewhat “gelatinous” appearance (this is quite natural, based upon the native characteristics of the substances involved). Do not fret over encountering such circumstances……they will not compromise the basic effectiveness of your protocol.
However, it is of some import to understand that the speed, and completeness, of the incorporation of the granular lecithin—into the aqueous medium, is affected by a number of conditions such as the total amount of lecithin versus the total volume of water; the temperature of the water-based solution and the strength of any other substance being incorporated into the parent solution-from very weak, to saturated (none of which are seriously compromising).
Under the best of conditions, even after ultrasonic mixing for 8 to 9 minutes….there is, often, a thin meniscus (a distinct separation between two or more liquids in the same container). [Example: a thin layer of oil lying on top of water.] In the liposome generation methodology we are discussing, the visible, gelatinous, portion of the meniscus is principally made up of unincorporated lecithin. Is IS NOT a problem, in fact the lecithin component has useful, cardiovascular, health-support effects-beyond those being discussed here.
Either (or both) of two measures may be executed to reduce the volume of unincorporated lecithin you may be encountering. First, increasing the volume of the total water fraction, or secondly, raising the temperature of the total parent solution and extending the time of US reaction exposure.
One reason for the condition you are encountering is that the closer one gets to achieving a saturated solution of lecithin….the more resistant the process becomes to accepting more granular lecithin into that solution until the point is reached where no further material will incorporate hence, THE SATURATION POINT IS EXPERIENCED.
In my brief, original post, I did not discuss the nuances of speed, degree or completeness of dissolution of the lecithin—-or for that matter— the ascorbic acid fraction. Neither did I outline a number of other considerations; such as the effects of varying the volume of water versus the ratios of the solution components ..or the total water volume versus the protocol components primarily, because such elaborations would not serve usefulness/effectivity for the nontechnical.
DIY person. I simply outlined a SAFE, mid-spectrum, protocol allowing the average lay-person to achieve a measure of acceptable results for home experimental research.
My personal bias is that it is better to have a small, uncombined, lecithin fraction presenting as a meniscus…..than to strive toward what I perceive to be a cosmetic achievement-of small consequence..by means of diluting the total solution. In any event the excess lecithin is a positive addition..it is just not active in the liposome process until some parameter changes that avails it the opportunity participate in the encapsulation process.
My final comment on this subject: If it is of paramount importance to one,regardless of reason. by just increasing the water volume and reactivating the US Cleaner for several minutes….the remaining lecithin will (in almost all cases) go into the emulsified solution. However, bear in mind, you have diluted the entire solution by an equivalent strength with NO increase in total vitamin C component.
Please understand, these comments are not meant to browbeat “anyone”….in any way….but, rather, to aid the less technically-informed on the list.
Sincerely, Brooks Bradley.
This entry was posted on 11. August 2009 at 15:26 and is filed under Supplements. You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response or trackback from your own site.
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13 Responses to “Make Your Own Liposomal Encapsulated Vitamin C”
admin says:
14. August 2009 at 21:43
Hello Everyone…
Today I bought everything I needed to make my Liposomal Vit-C. My ultrasonic cleaner was on sale so that was a plus…$24.95. I put everything together just like Brooks said and it all turned out the way he said would…so I took my first dose…the taste was not bad at all. I also bought some d-ribose powder and plan to make that into a liposomal concoction. I cannot wait to feel the results.
Best regards…
Sandy
admin says:
16. August 2009 at 16:03
From the Silver List.
Although not scientifically rigorous, I offer a simple test which will yield the DIY researcher some element of confidence that they do, in fact, have a useful measure of liposomal encapsulate.
First, pour about 4 ounces of your finished Vitamin C encapsulate into a cylindrical, 12 ounce water glass. Next, place 1/4 teaspoon of sodium bicarbonate into about 1 ounce of distilled water and stir for 3 to 5 seconds. Next, pour the sodium bicarbonate solution into the Vitamin C mixture and stir gently for several seconds.
Note: If the foam/bubble line which forms on top is 1/2 inch or less—in height—you have about a 50% encapsulation efficiency. If the foam/bubble line is 3/8 of one inch…or less, you have about a 60% efficiency.
If the foam/bubble line is 1/8 inch or less, you have about 75% efficiency. If the foam/bubble line is just a trace…..you should major in chemistry.
The percentages given above, represent the amount of the total Vitamin C component incorporated during the encapsulation process…..that was actually encapsulated. The less encapsulation….the greater the foaming.
What is, actually, occurring in this test is that the ascorbic acid fraction is being transformed into the sodium ascorbate form of vitamin C. This test does not negatively affect the usefulness of the solution you have tested…..as the isolated Vitamin C component is not adversely affecting the encapsulate (which is being protected by the lecithin bubble-covering.) Actually, the sodium ascorbate form of vitamin C is greater than an order-of-magnitude more soluble for tissue incorporation……than is the ascorbic acid form.
In any event this simple test should serve to raise the level of confidence in the DIY researcher…. that they do—in fact—have a useful measure of encapsulated vitamin C.
Sincerely, Brooks Bradley.
p.s. I had, a few moments ago, just finished a much more extensive posting…..but some form of invasive advertising spam flashed across the top of my mail system and in attempting to circumvent/nullify the invader
I lost my entire post. The actual post your are receiving is the product of my existing dismay. — The Silver List is a moderated forum for discussing Colloidal Silver .
admin says:
19. August 2009 at 16:18
Just to recapitulate (please correct me if I ‘ve got anything wrong):
1) + 2) The frequency and power of the ultrasonic cleaner (UC) seems to make not so much of a difference, and can be adjusted by increasing the duration of the dissolving process in the cleaner. Either a 50 watts, 42,000 cycles, $29.00, or a 160 watts, five preset cycles, $69.99 would work almost as well as a $500.00 lead zirconate titanate, research grade, unit.
3) As a source of phospholipids the dried granular form seems to give better results than liquid soya lecithin. About 3 level tablespoons of lecithin granules should be dissolved into 1 cup of distilled water.
4) The ratio of pure ascorbic acid powder to distilled water should be 1 level tablespoon (12 grams) in 1/2 cup of distilled water dissolved separately.
5) Both solutions are next poured in the UC - better in a separate glass due to concerns of corrosion of the stainless steel container - and slowly stirred while the cleaner is turned on. After about 6 minutes of ultrasonic dissolving the entire solution should be blended into a cloudy, homogeneous, milk-like mixture. Ready for oral use.
6) “The visible, obviously homogenized, portion of the solution” will keep acceptably at room temperature for 3 to 4 days. Refrigerated, it will keep much longer.
natvlegl says:
26. August 2009 at 17:23
Am I understanding correctly that encapsulating Vit C liposomatically will multiply the amount of C exponentially … like, grow more?? That is my understanding from reading it. Or does it just make the encapsulated C more bioavailable? Thanks for clarifying. ALSO … IF it does somehow multiply the amount of C by the process, would this also work with other water-soluble supplements?
Instead of soy lecithin, would polysaccharides of various kinds work to liposomatically encapsulate them also?
Thanks for your answer.
drhiii says:
26. August 2009 at 18:48
I like this technique a great deal. 7 years ago met Dr. Chen of Sunrider and he discussed his use of infusion of vitamins into food sources, making them bio available to the body. It was a very cool discussion, and also one that I did not know how to replicate.
This appears to be on the same plane. I’ve hoped to see this for a long, long time. So, kudos, and I will be participating in this going forward.
Oh, means I went out and acquired an Ultrasonic machines, some non Genetically-Modified-Organisms lecithin, ascorbic acid, and created my first brew. It worked. I sensed it worked very well. Ingestion of results, and one could sense this was a very cool protocol.
Loaded and mebbe premature question… what else does the author feel can be LET’d? Would lecithin remain the carrier or transport layer in this? And could say, minerals or similar things be infused?
This is great science, or not Science as the OP said, but it makes sense and my sense of the first results are very, very interesting. Me like…
mikeleekc says:
2. September 2009 at 22:16
Hi,
I noticed several websites offering many types liposomal supplements apart from Vit C.
This got me thinking whether I can use the same method outlined here to encapsulate other supplements like curcurmin/tumeric powder which has a very low bioavailability?
Best Regards,
Michael
leone says:
13. September 2009 at 16:06
Hello,
I have made several preps of lipo C ( using USC 2.5 liter model 95563 Chicago Electric Power Tools from Harbor Freight) as described by Brooks and all have worked well. I have tried several modifications:
1. increased the lecithin ( minimum 95% phosphatides) from 3 to as high as 6 tablespoons( 42.0 grams)
2. have used a power hand mixer with “wire beater” to mix lecithin…appears to “soluibilize” the lecithin much faster than the shaking time in a bottle
3. have used sodium ascorbate,calcium ascorbate and ascorbic acid…sometimes as a combo…amounts 16.6 to 89.0 grams
4.with high amounts of C I have used 4-5 cycles of 180 sec each( started with 90 sec but increased the last few)… have measured surface temp with digital laser thermometer…84-88 degrees F at the end of 5th cycle ( have not used heater)
5. have kept USC cover on last number of preps with 1 or 2 stirrings
Purchased a commercial liposome prep…8 oz bottle with 10 gm C/ounce…very syrupy
I have assumed that the commercial prep is getting a greater conc of lecithin to get
that high of a concentration of C
6. stored all preps in the refrigerator
admin says:
4. October 2009 at 11:21
Those reading this subject will further benefit from the discussion on Liposomal Vitamin C Absorbate accessed from the links on the left.
Administrator
girma1 says:
20. October 2009 at 00:36
Mike asked about possibly using the liposomal method above for encapsulating curcumin. I wondered too because of all the research and extremely positive outcomes for curcumin use. The problem is its very low bioavailability and insolubility in water.
So I’ve tried using the same lecithin and water mixture as with the liposomal vitamin C, then adding a tablespoon of curcumin powder to a warmed 1/2 cup of olive oil and heating further until the mixture suddenly goes clear (prior to boiling). Then I follow the same protocol as with the liposomal vitamin C: mix and blend the lecithin mixture and the curcumin-olive oil mixture together, and put the mixture through the three rounds of ultra-sound. The result is what appears to be a granule free liquid that can be poured onto or into almost any food you might choose. It keeps well in the fridge and hasn’t given me any trouble at all. The only difficulty of course is managing to keep free of the strong stain if you splash or spill any of the mixture.
I have no idea how to test the method for effective encapsulation. If anyone has a suggestion, please post.
cherye7 says:
21. October 2009 at 19:08
Hi. I’m sensitive to all forms of Vit. C except ascorbyl palmitate. If ascorbic acid bothers my stomach, will it still bother me after I put it in the UC? Will ascorbyl palmitate be OK to use instead? Thanks!
admin says:
6. November 2009 at 15:55
Cherye7,
Several others that had stomach problems with ascorbic acid found they had no problems taking their homemade liposomal Vitamin C. Best advice I can give is to try it. If you don’t want to buy the ultra-sonic unit without knowing try one of the commercial brands first.
-------------------------------------
- Liposomal Encapsulation Technology (... ladylove
14 y
44,327
This is a reply to # 1,556,980From:
//www.curezone.org/forums/fm.asp?i=1554530#i
From:
http://www.racehorseherbal.com/Infections/LET/let.html
Liposomal Encapsulation Technology (LET) is an exciting new process that may revolutionize many forms of oral pharmacological therapy and more importantly, may be in the realm of the common man to utilize.
LET can offer a unique safe way to treat racehorses in a track situation without the use of banned syringes or needles. It is simply an encasing of nanoparticles of pharmaceutical compounds (herbs, too) by a phospholipid membrane (liposome) allowing safe passage through the gastrointestinal tract without degradation.
It would be the closest thing we have to giving a pill that mimics an intravenous injection!
Plus, liposmes could more easily assault and penetrate many forms of infective biofilms resulting in a very effective delivery system against these pathological forms.
As an example, it has been shown that 5 grams of Vitamin C which has been encased by liposomes is equal to 50 grams of Vitamin C that has been given intravenously!
One can go out and purchase Liposomal Vit C and other compounds, but it can be made at home very cheaply. Certainly the home made Liposomal medications will not be quite as efficiently made as in the big med laboratories, but even if one can produce just 50% liposomal encapsulated material in the kitchen, that is more than good enough for our needs and can offer outstanding health benefits!
My book, A Racehorse Herbal will study in detail new and exciting breakthroughs like LET which will more effectively treat the performance horse and will be within the capability of any horseman to process himself!
Brooks Bradley has come up with a unique way to produce LET in your do-it-yourself Lab or kitchen for pennies. Most of his work has been done with Vitamin C. Vitamin C has very low absorbability in the gastrointestinal tract of humans (16%).
By encapsulating Vitamin C nanoparticles with a phospholipid membrane, we could directly by-pass the destructive forces of the gut with Liposomal-C being directly absorbed into the blood stream. He has manipulated the natural tendency of phospholipids to form tiny encasing bubbles (liposomes) in a water-based pharmacological solution.
The key is that these formed liposomes will automatically encase whatever is in the water solution with it. Thus, if you have an aqueous solution of Vitamin C, add soy lecithin (a common form of phospholipid easily purchased) and place the two solutions, together in even a cheap ultrasonic cleaning unit—you will get an automatic encapsulation via the ultrasonic waves to form Lipsomal-C.
This same process could be used for other compounds.
The respected researcher, Brooks Bradley writes,
"The implications are simply staggering. . .!
Our vitamin C Liposomal encapsulation protocol is as follows:
Using a small (2 cup) ultrasonic cleaner, like the ones sold at Harbor Freight for around $30.00, we performed the following:
1. Dissolved 3 level tablespoons of soy lecithin in 1 cup of distilled water.
2. Dissolved 1 level tablespoon of ascorbic acid powder (vitamin c) in half a cup of distilled water.
3. Poured both solutions together in the ultrasonic cleaner bowl and turned the unit on. Using a plastic straw (leaving the top of the cleaner open) gently, slowly, stirred the contents. Note: The cleaner will automatically self-stop every 2 minutes. Just push the ON button to continue. Repeat for a total of 3 series or 6 minutes total. By that time the entire solution should be blended into a cloudy, homogeneous, milk-like mixture. The LET solution is now formed.
4. This protocol furnishes about 12 grams (1200 mg) of vitamin C product at 70% encapsulation efficiency or 8400 mg of the LET type. This solution will keep at room temperature for 3-4 days. Refrigerated, it will keep much longer.
The homogenizing effect is so powerful that after 3 days at room temperature, no precipitation of solution separation appears evident. This type of sequestered vitamin c has demonstrated to be at least 5 times more effective than any other form of orally ingested vitamin c that we tested. Additionally, it appears to be even more rapid in tissue-bed availability than intravenously applications. An astounding revelation to us!"
More details in formulating liposomal Vitamin C:
Sometimes a meniscus (layer) can form in the completed LET solution. This can occur if the ultrasonic process is not run long enough or too much lecithin has been added in relation to the available ascorbic acid fraction (if one is making Vit C LET). In such case, the meniscus will form on top in minutes after completing the ultrasonic cycle.
More commonly, a meniscus will form on the bottom part of the LET solution overnight in some instances. One needs to continually experiment and adjust volumes to achieve the perfect homogenized LET solution that will withstand meniscus layering. Even if this happens, the solution is quite valuable and usable. You will just have a layer of lecithin within the LET solution and that in itself is of medicinal value and should not be discarded. Feed it all!
Lecithin is slow in forming liposomes in aqueous solutions especially when one has not added correct amount ratios of lecithin to the pharmacological solution to be encapsulated.
It is often natural to find a gelatinous mass of unencapsulated Lecithin floating on top of your LET solution. The encapsulation process is affected by amount ratios, temperatures of the solutions, and concentrations of the components.
One can limit this unencapsulated lecithin layer by increasing the volume of the total water though this has a diluting effect in the combined solution and/or raising the temperature of the solution. Increasing the ultrasonic mixing cycle may also be of value.
It should be noted that once the saturation point has been reached in the solution, no amount of adjusting will cause the lecithin to continue to encapsulate.
The guiding line for the amateur LET processor is that it is far better to have a layer of unencapsulated lecithin than to produce a solution with too little, no matter how pretty the final solution may look.
Brooks Bradley's simple test to gauge LET efficiency of a liposomal Vitamin C solution:
1) Pour 4 ounces of the finished LET Vitamin C into a 12oz container.
2) Add 1/4 teaspoon of sodium bicarbonate into 1 oz of distilled water, stirring well.
3) Pour the sodium bicarbonate solution into the LET Vitamin C mixture, stirring.
Results: If the resulting foam reaction line from this mixture is .5" or less you will have approximately a 50% encapsulation rate of the raw ascorbic acid nanoparticles. If the foam is 3/8" or less you will have approximately 60% encapsulation. If the foam is 1/8" thick or less, you will have around 75% encapsulation.
Foam occurs when the unencapsulated Vit C reacts with the sodium bicarbonate which is added to produce sodium ascorbate. The liposome encapsulated Vit C will not react. Thus, the less foam, the more Vit C is encapsulated and the more efficient went your process. By the way, this test solution should not be discarded as it is still valuable as a medicinal! The formed sodium ascorbate is a very useable form of Vitamin C.
Further useful tips from DaddyBob and Steve N. of the CS list: For best encapsulation efficiency, blend both the lecithin and your encapsulation solution very well, with a blender, magnetic shaker, or by pure mechanical shaking, until you see no granules or other large debris in solution—then place in the ultrasonic cleaner chamber. At least the use of a common kitchen blender is to be urged for pretreatment of solutions prior to ultrasonic process.
Brooks Bradley writes on this above suggestion:
"First, using some form of blender to enhance/accelerate the process is perfectly acceptable and effective. However, one must understand the limitations of using this modality. To wit: Because the entire encapsulation process is, essentially, a refined homogenization process the researcher is bound within the limits of the chosen process, itself; Using a blender in the early stages of the ultrasonic type protocol, places a limit (especially particle size) on the resultant compounds.
As a general rule, the smallest liposomes achievable are going to be larger than 150 nm in size----even after extensive agitating. Therefore, if smaller particles are desired--some procedure must be invoked to achieve this.
Ultrasonic energy is an excellent way to achieve this. Ultrasonic energy applied to solutions having, previously been mixed using mechanical blenders (household type) will improve the encapsulation process greatly (sometimes as much as an order of magnitude) through the immediate size reduction of the encapsulated particle size.
Additionally, both power levels and exposure time experienced from the ultrasonic energy have a pronounced effect on the end product: e.g. simply by extending the time exposed to the ultrasonic energy will yield a product with a majority of particles of a markedly reduced physical size (sometimes by more than one-half).
Also, by increasing the power spectral density [energy delivered to the target], considerable size and complexity reduction may be achieved (sometimes from larger, multiple-layered liposomes, down to single-layered liposomes of much smaller size). This one characteristic, alone should justify the selection of the larger ultrasonic unit over the smaller one as the larger ultrasonic power level output is much higher.
The way to capitalize on this advantage is to limit the depth of the parent solution in the larger ultrasonic unit to 3/4"- 1" deep. Because the distance from the ultrasonic energy source and the mass of the target material DOES, in fact, have a powerful effect on the delivered energy.
Direct visual observation alone will confirm the powerful increase in cavitations (energy field) of the liquid medium. This type of innovation will yield effects that in some cases challenge the results of laboratory-grade, high pressure (over 3000 psi) impact plate systems costing $10,000 and up.
What most commercial producers (and labs) do is they RECIRCULATE their candidate
solutions in order to achieve smaller and more isolated end products.
By extending your exposure time using shallow solutions, do-it-yourselfers can in many cases actually challenge the levels accomplished by these very high dollar commercial machines using their own do-it-yourself homemade systems.
Someone asked the question: does pre-agitation via kitchen blending devices damage or
compromise the candidate solutions. The short answer is NO. Almost any type of agitation, aids in the homogenization process."
- Dr. Thomas Levy's presentation to th... ladylove
14 y
40,813
This is a reply to # 1,556,982From:
http://www.naturalhealthstrategies.com/vitamin-c.html
This is a 4-part video series of Dr. Thomas Levy at the 35th Annual Tree of Life Cancer Convention, on the breakthrough effectiveness of Liposomal Encapsulated Vitamin C
You can download the 4 (10-minute) videos into Realplayer (A free program) if you have it, I did..
Please go and listen to them- According to this Dr., it's better made and orally ingested the ultrasound way than by IV, he tells you why on the videos.
-------------------------------------------------------
Good Health to All of Us,
Ladylove
- DIY Liposome - Encapsulated Vitamin ... ladylove
14 y
42,762
This is a reply to # 1,556,989..you can make the LE Vit C with Sodium Ascorbate by adding 1 TBSP (I use Bob's Red Mill, non-Aluminum) Baking Soda to the Ascorbic Acid before dissolving it in the water.
Otherwise, follow the recipe exactly as given, except you must mix the Vit C powder in a 32-oz container, adding water slowly and stirring until the fizzing stops. Then proceed exactly the same with the rest of the process.
The finished LET C will have a slight salty taste and no bite at all.
Note: Drink a lot of water after drinking this, it's important to help it work.
Good Health to All of Us,
Ladylove :)- Re: DIY Liposome - Encapsulated Vita... yukkuri
14 y
36,544
MoreThis is a reply to # 1,563,581Wonder what other uses are evolving for DIY lyposomal treatments. Would this be useful for getting herbs like cayenne or turmeric into the body? Colloidal Silver ? Anyone out there experimenting with this?
Also wondering what else may be used for lyposomal encapsulation besides lecithin?
Further, I am wondering if adding lecithin to raw or superfood food smoothies would enhance bioavailability? Certainly have heard of adding coconut oil to smoothies to assist with intake of fat soluble vitamins.
Wondering if there is a relationship here with Budwig?
Curiouser and curiouser...- Re: DIY Liposome - Encapsulated Vita... yukkuri
14 y
37,400
This is a reply to # 1,613,676The wikipedia page on lyposomes is informative at a basic level, especially this paragraph:
"Targeting cancer
Another interesting property of liposomes are their natural ability to target cancer. The endothelial wall of all healthy human blood vessels are encapsulated by endothelial cells that are bound together by tight junctions. These tight junctions stop any large particle in the blood from leaking out of the vessel. Tumour vessels do not contain the same level of seal between cells and are diagnostically leaky. This ability is known as the Enhanced Permeability and Retention effect. Liposomes of certain sizes, typically less than 400 nm, can rapidly enter tumour sites from the blood, but are kept in the bloodstream by the endothelial wall in healthy tissue vasculature. Anti-cancer drugs such as Doxorubicin (Doxil), Camptothecin and Daunorubicin (Daunoxome) are currently being marketed in liposome delivery systems."
http://en.wikipedia.org/wiki/Liposome
- Morphological observations on the fa... yukkuri
14 y
35,896
This is a reply to # 1,613,686
Interesting abstract... if I am reading correctly, lyposomes tend to accumulate in the lymph system. It also appears that they used a Colloidal Gold solution for forming the lyposomes, which answers one of my questions.
So far, it seems like lyposomes are a great delivery vehicle that seem to end up in in lymph nodes and tumor locations....and to top it off, cheap and easy to make.
-yukkuri
http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1X-3VXBT4P-8&_use...
"Morphological observations on the fate of liposomes in the regional lymph nodes after footpad injection into rats
Multilamellar liposomes composed of equimolar egg phosphatidylcholine and cholesterol and containing carboxyfluorescein or Colloidal Gold were injected subcutaneously into the footpad of the hind-leg of rats. The draining popliteal lymph nodes of animals killed at time intervals after injection were then dissected and sections examined by fluorescence microscopy (carboxyfluorescein), light microscopy using an immunogold silver kit to enhance gold particles or by transmission electron microscopy. Morphological observations confirmed that subcutaneously injected liposomes accumulate in large numbers in the draining lymph node. The majority of liposomes arrived at the subcapsular sinuses, probably via afferent lymphatic vessels, as such, i.e., in a non-cell bound form. Subsequently, liposomes were dispersed throughout the lymph node either by permeation as free vesicles along the sinuses or by cells involved in vesicle uptake. The majority of such cells were free macrophages, littoral cells and reticular cells (fixed macrophages). Once within cells, liposomes were seen digested by the lysosomal apparatus with varying loss of their lamellar structure, leaving free gold particles within the lysosomes.
Author Keywords: Liposome; Lymph node; Morphological observation; Immunogold electron microscopy"
- Morphological observations on the fa... yukkuri
14 y
35,896
- Re: DIY Liposome - Encapsulated Vita... yukkuri
14 y
37,400
- Re: DIY Liposome - Encapsulated Vita... Rosemary9
10 y
14,664
This is a reply to # 1,563,581I maybe should have put my most recent post here instead therefore, I am repeating it and would love your take on the below info.
I believe it might be worth noting that the ph in the finished product should be measured as this solution is going directly into the blood stream. Although, I may have over looked it as I read through the posts I did not see anything mentioned about the ph level.
Blood pH is tightly controlled by the body at near 7.35 pH. If your blood pH were much above or below that number you would be a very sick person.
Therefor, in testing this recipe it will hopefully give you a product between 7.0 and 7.5 ... or similar pH to human blood so there is no risk of over acidifying/alkalizing your blood should you take significant amounts of your homemade Liposomal Vitamin C Ascorbate.
Info taken from:
quantumbalancing m/liposomalC
However, I followed the recipe (with the baking soda) on the above mentioned site prior to discovering the curezone mentioned recipe and the ph was well beyond an 8. It may have been a mistype but, 1 Heaping Tablespoon of Bicarbonate of Soda in 2 oz. of distilled water blended into the solution is apparently way too much.
Any further thoughts on this is great. Thanks.
- Re: DIY Liposome - Encapsulated Vita... yukkuri
14 y
36,544
- DIY Liposome - Encapsulated Vitamin ... ladylove
14 y
42,762
- Re: Liposomal Encapsulation Technolo... Rosemary9
10 y
14,483
This is a reply to # 1,556,982I believe it might be worth noting that the ph in the finished product should be measured as this solution is going directly into the blood stream. Although, I may have over looked it as I read through the posts I did not see anything mentioned about the ph level.
Blood pH is tightly controlled by the body at near 7.35 pH. If your blood pH were much above or below that number you would be a very sick person.
Therefor, in testing this recipe it will hopefully give you a product between 7.0 and 7.5 ... or similar pH to human blood so there is no risk of over acidifying/alkalizing your blood should you take significant amounts of your homemade Liposomal Vitamin C Ascorbate.
Info taken from:
quantumbalancing m/liposomalC
However, I followed the recipe (with the baking soda) on the above mentioned site prior to discovering the curezone mentioned recipe and the ph was well beyond an 8. It may have been a mistype but, 1 Heaping Tablespoon of Bicarbonate of Soda in 2 oz. of distilled water blended into the solution is apparently way too much.
Any further thoughts on this is great. Thanks.
- Dr. Thomas Levy's presentation to th... ladylove
14 y
40,813
- Re: Homemade (With ultrasound) Lipos... ranfurly44
12 y
33,729
This is a reply to # 1,556,980This is in response to the comment about encapsulating Curcumin to increase bioavailability. In fact you can get much greater bio-availability of Curcumin (a reported 20X) by either adding black pepper extract (piper nigrum) by taking a product such as Source Naturals' BioPerine 10 mg or by buying a product that already has the black pepper extract included (Vitacost has one such).
After I learned about the increased bioavailability of Vitamin C when lypospherically encapsulated, I was pleased to learn about the effect that Black Pepper can increase the bioavailabity when I read the comments in a Curcumin product that included 5 mg of Black Pepper Extract in the capsule.
I buy the combination product for my wife and use the BioPerine myself as I am presently taking prescription meds as a result of a heart attack and stent. I take use the pepper once a day as far away from the time I take meds as possible so as not to push my luck in case this also increases the bioavailability of whatever other substances are in my blood.
I have been purchasing encapsulated Vitamin C, and have only yesterday learned about a method for making it at home while searching another site. The relatively new article I found is at http://zapperexperts.com/
and has a video that shows how the site owner makes his version, and there are also excellent comments there as well
I found this article today and want to thank everyone for the excellent information as it will almost certainly ensure that my first batch will be better than it would have been without your kind assistance.
Here's a snippet from a webpage on the efficiency of Bioperene as a bioavailability enhancer for Curcumin.
I'm sure that there are other such synergistic combinations, and I look forward to learning and sharing those that I find.
Piperine is a pungent compound found in the fruit of the plants in the Piperaceae family, the most famous member of which is Piper nigrum, black pepper. It has a long history of use in Ayurvedic medicine as a restorative and treatment.
Piperine is able to increase bioavilability of many substances through a number of mechanisms. It inhibits several enzymes responsible for metabolizing nutritional substances, stimulates amino-acid transporters in the intestinal lining, inhibits removal of substances from cells so they continue to be available for use, and decreases the intestinal activity allowing more of the substances to enter the body in active form. The results of these actions are that substances reach, enter and remain within their target cells for longer periods of time than would normally be the case.
Piperine can turn a marginally effective therapeutic substance into a highly effective one by increasing its bioavailability and intracellular residency time. As an example, piperine can increase the bioavailability of the cancer, inflammation and infection fighter, curcumin, by twenty-fold.
The medicinal properties of various compounds such as curcumin cannot be well utilized because of poor bioavailability due to its rapid metabolism in the liver and intestinal wall. In an older study reported in Planta Medica, the effect of combining piperine, a known inhibitor of hepatic and intestinal glucuronidation, was evaluated to determine the bioavailability of curcumin in rats and healthy human volunteers. When curcumin was given alone to the rats, moderate serum concentrations were achieved over a period of 4 hours. When piperine was added with the curcumin, the serum concentration of curcumin increased for a 1-2 hour period. Time to maximum concentration was significantly increased while elimination half life and clearance significantly decreased. The bioavailability was increased by 154%. When curcumin was given alone to humans, serum levels were either undetectable or very low. Addition of piperine produced much higher concentrations from 0.25 to 1 hour following administration. The bioavailability of curcumin when taken with piperine increased 2000%.
Learn more: http://www.naturalnews.com/024829_piperine_curcumin_black_pepper.html#ixzz1nz...
- Re: Homemade (With ultrasound) Lipos... ranfurly44
12 y
29,963
This is a reply to # 1,556,980There has been a lot of discussion and searching to find a non-gmo soy free solvent-free source of Lecithin on the Yahoo LET DIY Vit C group, and the current info may be of some interest to members and users of this mega-forum.
Of all the sources available commercially at this time, it appears that liquid Sunflower lecithin is preferable to any Soy granules, and only one supplier is offering a solvent-free Organic variety.
That supplier is Lekithos Inc who offer a variety of qualities - with the best - as would be expected - also being the most expensive.
That would be their "100% Organic Liquid Sunflower Lecithin"
See it at http://www.mysunflowerlecithin.com/100-organic-liquid-sunflower-lecithin/#con...
The current price is $27.99 per lb and $48.99 per 2 lb plus shipping
Given the benefits to be had from the LET DIY Vit C, unless another source comes available, even with the price of lecithin being at this level, the overall cost of the finished DIY product will still be considerably less than the commercial retail products.
In addition, the commercial product is most likely produced with Soy Lecithin as the preferred product shown above has only been on the market for a very short time.
For anyone brave enough to take a chance on organic non-gmo Soy, Clarkson Soy Products offers such a product at
http://www.clarksonsoy.com/organic-lecithins.php
Their ?best choice could be their PC 1000 Organic Soy Lecithin.
Will update this information from time to time as new information becomes available.
Anyone wanting to get involved may want to have a look at
http://health.groups.yahoo.com/group/DIY-LET/
- Liposomal Encapsulation Technology (... ladylove
14 y
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- Homemade (With ultrasound) Liposomal... ladylove
14 y
53,276
- Re: Cancer-Killing Effect Of High Or... patientadvocate
12 y
28,950
This is a reply to # 1,556,665Thank You for this posting.
We could not justify the cost of traditional liposomal products without hard or raw data.
The questions I have are:
1) can you provide links to the raw data that compares liposomal vitamin c to IV-c?
2) Isn't tissue saturation the end all and be all...I mean once your tissues are saturated how can you possibly increase the concentrations higher? Am I missing something?
Bret Peirce
American Cancer Advocates- Re: Cancer-Killing Effect Of High Or... chrisb1
12 y
28,907
This is a reply to # 2,002,639Bret,
Best to read this, but essentially no I cannot provide the raw data.........................
http://www.drlam.com/articles/liposomal_encapsulation_technology.asp
Best to contact Dr Stephen Hickey and Hilary J. Roberts, who wrote about Ascorbate in their well-known book concerning tissue saturation of the same, but what was thought to be a maximum oral dose, for the maximum tissue saturation was not the case according to their research.
Chrisb1.
- Re: Cancer-Killing Effect Of High Or... chrisb1
12 y
28,907
- Re: Cancer-Killing Effect Of High Or... InCharge
14 y
35,906
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