Candida, in the moment it is attacked by the immune system of the host or by a conventional antifungal treatment, does not react in the usual, predicted way, but defends itself by transforming itself into ever-smaller and non-differentiated elements that maintain their prolific reproductiveness intact to the point of hiding their presence both to the host organism and to possible diagnostic investigations.
The Candida's behavior may be considered to be almost elastic:
When favourable conditions exist, it thrives on epithelium (a surface such as the inner surface of intestines); as soon as the tissue reaction is engaged, it massively transforms itself into a form that is less productive but impervious to attack -- the spore.
If then continuous sub-surface anti-fungal solutions take place coupled with a greater reactivity, in that very moment the spores go deeper into the lower connective tissue in a well defended impervious state.
In this way, Candida is free to expand to maturation in the soil, air, water, vegetation, etc., that is, wherever there is no antibody reaction.
In the epithelium, instead, it takes a mixed form, that is reduced to the sole spore component when it penetrates in the lower epithelial levels, where it tends to expand again.
Candida has been studied only in a pathogenic context, that is, only in relation to the epithelial tissues. In reality Candida possesses an aggressive ability that is diversified in response to the target tissue. It is just in the connective or in the connective environment, in fact, and not in the differentiated tissues, that Candida may find conditions favourable to an unlimited expansion. This emerges if we stop and reflect for a moment on the main function of connective tissue, which is to convey and supply nourishing substances to the cells of the whole organism. This is to be considered as an environment external to the more differentiated cells such as nervous, muscular, etc. It is in this context, in fact, that the competition for food takes place. On one hand we have the organism's cellular elements trying to defeat all forms of invasion; on the other hand, we have fungal cells trying to absorb ever-growing quantities of nourishing substances.
Candida goes deeper into the sub-epithelial levels from which it can be carried to the whole organism through the blood and lymph (intimate mycosis). Stages one and two are the most studied and known, while stage three, though it has been described in its morphological diversity, is reduced to a silent form of saprophytism (obtaining food by absorbing dissolved organic material).
The fungal expansion in fact becomes greater as the host tissue becomes less nutritious to the candida, and thus less reactive against it.