Since many of us came to Iodine
because of less than optimal thyroid function as well as adrenal fatigue. I was interested if any of you have tried supplementing Pregnenolone or DHEA in conjuction and what you thought?
I've read about pregnenolone before but recently came across it again in this article. http://www.tidesoflife.com/pregprodhea.htm
REPAIR OF ENZYMES: Pregnenolone apparently has the ability to repair enzyme activity. For example, in a Russian research study, adding pregnenolone to a mitochondrial suspension increased the enzyme activity. Which enzyme The enzyme which converts cholesterol into pregnenolone (one in the P-450 system). Other enzymes in the P-450 system vital to certain detoxification processes are also stabilized by pregnenolone.
Peat says, "…steroids, including cholesterol, have an anti-toxic effect. The cytochrome P-450 family of enzymes is an important factor in our resistance to toxins. Moderate amounts of cortisol promote this system, but larger amounts degrade it. Pregnenolone doesn’t affect the rate of synthesis of these enzymes, but it stabilizes them against the normal proteolytic enzymes, increasing their activity. I believe this stabilizing action is a general feature of these steroids…"
MEMORY REPAIR: In a short article in The Sacramento Bee (Tuesday, March 3, 1992) I read that Pregnenolone may help restore impaired memory, according to neurobiologist Eugene Roberts of the City of Hope Medical Center in Los Angeles, and his colleague, biologist James F. Morely, of the St. Louis VA Medical Center. These researchers tested pregnenolone and other steroids on mice. They found that pregnenolone is several hundred times more potent than any other memory enhancer that has been tested before is. Their report, in the Proceedings of National Academy of Sciences (March 1992), says that pregnenolone was used in the late 1940’s to treat Rheumatoid Arthritis
, and quite successfully, but fell into disuse when cortisone was discovered. But, Roberts adds, pregnenolone was never found to have adverse side effects whereas the toxic effects of cortisone are many and severe.
PROTECTION FROM CORTISONE TOXICITY: The classic effects of toxic levels of cortisol include daytime euphoria, insomnia plus hot flashes at night, osteoporosis, brain aging, atrophy of the skin plus other signs of premature aging and adrenal atrophy (shrinking). Two injections of cortisone can destroy the beta cells of diabetes in people as well.
Peat reports that pregnenolone can be used to withdraw from cortisone therapy over a one month period without developing "Addison’s" disease symptoms (from adrenal atrophy), because of its normalizing effects on the adrenal gland. In female patients, progesterone therapy may also be indicated.
Reduced exophthalmia in Graves’ disease patients: In the 1950’s pregnenolone was tested on patients with exophthalmis (bulging eyes) from Graves’ disease. It was reported that their eyes quickly receded to a more normal position in their sockets. Peat gave pregnenolone to a desperate woman with seriously bulging eyes. The next day she phoned him and said her eyes were completely normal."