I generally tell patients to "back off" treatment a little once they feel they are getting immune involvement during candida treatment, there is NO need to suffer with a Herxheimer reaction. In fact, some Japanese research into candida I've seen has revealed that die-off can ultimately achieve what you don't want - it weakens immunity and thus sets treatment back, and it can make candida secrete toxins like gliotoxin which can seriously weaken immunity. When candida die, they can release cell wall fractions known as mannan that can also weaken immunity and set your treatment back. There is no real need to have to endure die-off, just reduce treatment and fly under the radar. Google can telly you more about gliotoxin and mannan. I've researched candida for many years and tend to treat patients quite differently from how I did many years ago.