Here is what Dr Lam has to say about all these.
1. Licorice Root
Licorice (Glycyrrhiza glabra and Glycyrrhiza uralensis) is grown in Europe and Asia. Licorice is a highly prized Chinese medicine. It is used in almost all of the Chinese patented herbal formulas. Licorice is the most well known herb for adrenal support. It is an anti-stress herb known to increase energy, endurance, and vitality and act as a mild tonic. Licorice is known to naturally fortify cortisone levels and it has been used to help decrease symptoms of hypoglycemia, a common side effect of decreased adrenal function. It causes increased production of aldosterone, a hormone that is frequently deficient in advanced Adrenal Fatigue. A rise in blood pressure may be experienced in those who are normal. Licorice candy does not offer the same benefits as preparations made from the root, but can cause an increase in blood pressure.
Licorice can soothe nervous stomachs and stimulate both blood circulation in the heart and arteries and production of interferon-like substances by the immune system.
Licorice was prescribed for Addison's disease until the 1930s. Deglycyrrhized licorice (DGL) is made by removing the glycyrrhizin. For positive adrenal effects, only real licorice should be used, not DGL.
Long-term use of licorice containing more than 1 gram of glycyrrhizin (the amount in approximately 10 grams of licorice root) daily can cause increased blood pressure and water retention (edema) (Schambelan 1994). It should not be used in pregnancy.
Side effects of licorice include headache, hypertension, lethargy, upset stomach, diarrhea, facial puffiness, edema, increased fatigue, anxiety, irritability, and grogginess. It may potentiate the effect of warfarin and digoxin therapy. These side effects are more prominent in those with advanced Adrenal Fatigue. The weaker the adrenals, the more stimulatory the side effects can be anticipated. Most of the side effects are associated with what appears to be the loss of adaptogenic properties, resulting in a propederance of stimulatory properties.
2. Ashwagandha Root and Leaf (Withania somnifera)
Ashwagandha is an ancient Indian herb with a history of therapeutic uses. Known as a tonic for all kinds of weaknesses, ashwagandha is famous for its direct benefits for the adrenal tissue and function of the adrenal glands. Ashwagandha promotes strength and vigor while also regarded as a rejuvenator and mild aphrodisiac.
Ayruvedic physicians use ashwagandha as the treatment of choice in rheumatic pains, inflammation of joints and other related conditions. Ashwagandha is considered to be an adaptogen, a substance that helps the body return to normal levels. For instance, if cortisol is too high, ashwagandha lowers it. If cortisol is too low, ashwagandha raises it. Under a normal therapeutic dosage, ashwagandha side effects are not present if it is used more than 180 days, with intermittent holidays if high dose is used. It is generally well tolerated and without any significant side effects. No significant drug interactions have been found.
Some people have complained of slight drowsiness after using it while with a majority of people have had no trouble at all if they are constitutionally strong. Those with advanced Adrenal Fatigue may find this herbal compound become stimulatory, increasing energy. Like licorice, the stimulatory properties tend to be exaggerated and may become too pronounced in a setting of advanced adrenal weakness, leading to anxiety and a sense of being "wired". As such, it should be closely monitored if used in such settings.