Water retention is a common side effect of Sporanox. If you have not seen any improvement in your lips at the beginning of 4 weeks, I do not know if you will. You could still have candida, but maybe not the type that Sporanox targets.
If you believe you have candida, I would try the kefir and saccharomyces boulardii probiotics along with the nystatin enema.
I am no longer taking Sporanox. My lips are still healed, but I am afraid it might spread again since Sporanox/Diflucan does usually get rid of candida in the intestines. I am going to start taking probiotics with the saccharomyces boulardii strain. Since it is a yeast itself, maybe that is why it is better able to target candida than strains of bacteria probiotics. I am also considering a daily enema of nystatin for 1 month to address the intestines.