tried oral dosage of Moxidectin around 24-30mg divided into 5 times to take. Because Moxidectin is more toxic than ivermectin.
Why Moxidectin? I found that my oral absorption of praziquentel is worse and worse, and the worms become resistant. It could be because that Long term dose of Praziquentel simulated the expression of P-gp a transportor protein in the Gut wall that will kick out the drugs from the Gut, in addition, P-gp is also stimulated on the wall of the worms, thus, the worms become resistant after a while . Ivermectin is a substrate of P-gp,therefore it has very bad absorption by doing orally. That's why ivermectin injection saved many people. I have to say this is the best approach so far which completely stopped the itchiness on the body, and the movement of the worms, so that I could have a normal life. Except that it's quite pain to do the injection. I have the Moxidecin for a while, and I did not use it because somebody on the web claimed that they had very bad side effect. This time I read the other posts carefully, and many scientific papers about the pharmacokinetics of moxdectin, and decided to give it a try. Moxidectin is not a strong substrate of P-gp, therefore the oral absoprtion is better, and worm resistance is less.