J Autoimmun. 2016 Dec;75:50-57. doi: 10.1016/j.jaut.2016.07.008. Epub 2016 Jul 21.
promotes apoptosis of thyroid follicular epithelial cells by inducing autophagy suppression and is associated with Hashimoto thyroiditis disease.
Xu C1, Wu F1, Mao C2, Wang X1, Zheng T1, Bu L1, Mou X1, Zhou Y3, Yuan G1, Wang S4, Xiao Y5.
The incidence of the autoimmune thyroid disease Hashimoto thyroiditis (HT) has increased in recent years, and increasing evidence supports the contribution of excess Iodine
intake to thyroid disease. In this study, we examined the status of autophagy and apoptosis in thyroid tissues obtained from patients with HT, and we determined the effects of excessive Iodine
on the autophagy and apoptosis of thyroid follicular cells (TFCs) in an attempt to elucidate the effects of excess iodine on HT development. Our results showed decreases in the autophagy-related protein LC3B-II, and increases in caspase-3 were observed in thyroid tissues from HT patients. Interestingly, the suppression of autophagy activity in TFCs was induced by excess iodine in vitro, and this process is mediated through transforming growth factor-β1 downregulation and activation of the Akt/mTOR signaling pathway. In addition, excess iodine induced autophagy suppression and enhanced reactive oxygen species (ROS) production and apoptosis of TFCs, which could be rescued by the activation of autophagy. Taken together, our results demonstrated that excess iodine contributed to autophagy suppression and apoptosis of TFCs, which could be important factors predisposing to increased risk of HT development
In addition, I've SEEN this happen to my patients before I even read about high doses of iodine causing this. Their 24 hour urine iodine was off the charts, the we're over saturated & paid for it at the hospital. I'm only a messenger, everyone has the right to do with their bodies what the want. However, I'll all about INFORMED DECISIONS, lots of people if they only knew would have done otherwise
At least with all the info one can decide for themselves.