There are three factors: Excretion rate,amount of mercury poisoning and sensitivity. The amount of mercury in your body/brain may depend on how well your body can excrete the poison. How it affects you will depend on the amount and the sensitivity. A person with a high sensitivity may not be able to tolerated a single serving of fish or a calcium supplement made from seashells. I have not bothered with the candida issue myself,but it is very clear to me that the mercury going into your gut is significant. I now have about 40 percent of the intestinal gas that I had before with 18 amalgams. And my bad breath is gone after removal.