you can take ORTHO up to 8 capsules before bedtime. That is the max... but... instructions say to start out with 1 pill, work your way up to 3.. and them see if you can sleep on your own... personally, I need about 6-8 to sleep well ... The Arigine.. one when you wake up, one before lunch and one before 3 pm.. otherwise you will be awake all day.... I take one Arigine in the morn and It keeps me going.... until around 3pm, then I get tired..... hope it helps!
Happy Detoxing Tox!