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Resveratrol and Herpes
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Published: 15 years ago

Resveratrol and Herpes

Encouraging news...

Resveratrol inhibition of herpes simplex virus replication.
Docherty JJ, Fu MM, Stiffler BS, Limperos RJ, Pokabla CM, DeLucia AL.

Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown 44272, USA.

Resveratrol, a phytoalexin, was found to inhibit herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) replication in a dose-dependent, reversible manner. The observed reduction in virus yield was not caused by the direct inactivation of HSV by resveratrol nor inhibition of virus attachment to the cell. The chemical did, however, target an early event in the virus replication cycle since it was most effective when added within 1 h of cell infection, less effective if addition was delayed until 6 h post-infection and not effective if added 9 h post-infection. Resveratrol was also found to delay the cell cycle at S-G2-M interphase, inhibit reactivation of virus from latently-infected neurons and reduce the amount of ICP-4, a major immediate early viral regulatory protein, that is produced when compared to controls. These results suggest that a critical early event in the viral replication cycle, that has a compensatory cellular counterpart, is being adversely affected.

PMID: 10551373 [PubMed - indexed for MEDLINE]


Other links are available at that site. Those other links have more recent and more encouraging findings.

I have been taking's product (bid). I have no affiliation (but I wish I did. This product is expensive.). What has become Longevinex's product was used in the famous testing by David Sinclair of the Harvard Medical School (now reportedly suing Longevinex for keeping him out of the profit loop). According to the website which cites independent testing and results, Longevinex's product is besting the competing products, hands down.

I have tried so many ways-and-means to slow or stop Herpes that I now have guarded enthusiasm at every turn. However, in this case, I have been outbreak free for one month. In this one month, I have traveled internationally, and when I do travel, I typically have an outbreak during or after, probably due to the stress of travel (and especially dehydration endemic with flying). So far so good. The other cause for cautious optimism is sense of freedom I feel from viral activity that has always been a part of Herpes.


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