Is there any solid factual evidence of this mutatation theory? What I can say for myself and others that I know personally is that Diflucan and Nystatin does help alot. My relapse is due to making very bad diet choices, I cannot blame the drugs, or anything else. Also even with a relapse I am no were near as sick as I was 3 years ago when I started Diflucan and nystatin. My relapse is minor in comparasion to me being full blown candida sick. Having said that I also believe that garlic, Oregano, GSE, colon cleanses, Liver Cleanses all help as well and I use all as well, but other antifungals did nothing for me. This whole journey is very individual, everyone needs to find what works for them and know that people heal from this. I personally know 5 people who are fully recovered and they all attribute thier recovery to a long term candida diet with some sort of antifungals, (70% of the cure is diet and 30% is antifungals I was told) some did cleanses other did not, but as far as they are concerned there is no black magic to thier cures it was just simple dedication to the diet and thier health. If you kill it and stop feeding it for a long enough period of time than you will have solved your problem.