I have Bipolar Disorder type 2 which is a little lesser on the manic side. Meds never helped me much either. To be honest psychotherapy helped more then the meds. Now I am trying supplements. I also have alot of heavy metals in my body but I dont know how the heck I got them like Mercury and Tin especially. I dont have dental fillings.
Here is what I am doing with some success
Take Omega 3 Fish Oil Capsules (make sure Mercury/chemical free) 3 times day
Armour Thyroid (thyroid is messed up after years of meds)
Dr Schultz Superfood
Pregnenlone (adrenal support)
Vitamin C...500mg 2 times a day
I am not Cured yet but i have found this to help a lot.
I still take 100mg of Seroquel a night to sleep I am trying to work off of this but I think it will take some time.