I can't wait to see the answer to this, because I'm the same way. For the last week, I have gotten NO sleep, I'm achey, and extremely irritable. I cry at the drop of a hat. I'm very constipated, have a lot of gas, and am very depressed. I got my thyroid checked, and it's normal. So I don't know what could be wrong. My husband has sailed through HumaWorm with no problems-he loves it. I'm miserable myself.