Yes Trap I think micro electricity to the knee as well as magpulsing would speed the healing process. I am a huge proponent of light therapy be it LED or laser. Laser is prefered for deeper penetration of the muscle, tendons, cartiledge etc. I am so into this stuff I designed my own laser for healing and bio-stimulation, it's on my site. A quick web search yielded the following on the supplements I mentioned.
Treating Knee Arthritis With Hyaluronic Acid
Knee osteoarthritis can be a painful and disabling problem. Physiatrists are highly trained in cutting edge, non-surgical treatments based on the latest medical information available. Some physiatrists are involved in ongoing research on hyaluronic acid used in conjunction with exercise to relieve arthritis pain.
Hyaluronic acid is an important part of normal knee joint fluid
Hyaluronic acid plays a role in joint protection and lubrication
Individuals suffering from osteoarthritis have less hyaluronic acid in the synovial fluid in their joints leading to poor joint lubrication and increased pain
Numerous studies have found injectable hyaluronic acid to be safe in humans and effective in decreasing pain and improving function
MSM is impressively effective for muscle aches, and may help alleviate:
Joint, back, dental pain
We highly recommend supplementation of MSM for general aches and pain as well as a joint lubricant for arthritis sufferers.
Organic sulfur has been extremely successful for our customers in providing relief for joint and (fibromyalgia) muscle pain, indigestion and skin problems. We recommend taking between four and six grams per day. MSM works well with glucosomine to rebuild supportive tissue.
MSM strengthens the synthesis of connective tissue and improves joint function. MSM neutralizes acidity in the blood. MSM has amazing healing properties for the skin.
MECHANISM OF ACTION OF ALOE VERA: WOUND HEALING
The concept that the Aloe vera molecule synergizes with plant growth factors to repair and produce growth, broadly portrays the activity of Aloe vera . Three characteristics of growth factor activity in Aloe are:
inhibition of pain & inflammation
stimulation of fibroblasts to functionally produce collagen & proteoglycans
increased wound tensile strength
The mechanism of Aloe's inhibition of pain and inflammation will be detailed in the next section, first we must understand how Aloe vera enhances wound healing.
During the healing process, Aloe vera's stimulation of the fibroblast produces and adds new collagen to tissue. However, we should note that macrophages can also secrete substances that can similarly stimulate fibroblasts. Whether the effect is direct (from Aloe) or indirect (from macrophages), new collagen forms between the margins of wounds when Aloe is present. These collagen bonds are responsible for increased tensile strength. Therefore, if the tensile strength increases, it is assumed the collagen productions is increased by Aloe. This is a different approach than the Danhof response of Aloe based on the uptake of tritiated thymidine, which only represents an increase in fibroblasts number. Whereas, we are demonstrating a functional increase in collagen and proteoglycans through wound tensile-strength.
When skin is injured, fibroblasts migrate into the wound area to proliferate and produce collagen as well as proteoglycans. Proteoglycans form the ground substance in which collagen fibers embed. This represents a remodeling of connective tissue. Cells in the wound area communicate with each other by growth factors. Growth factors in Aloe are attracted to the wound area and bind to the fibroblast IGF receptor to produce collagen and proteoglycans which increase the tensile strength .
Connective tissue is mainly composed of collagen, which makes up one third of our body protein. Also, connective tissue contains large complex chains of modified sugars that form the framework for collagen. These modified sugars hold water and give connective tissue flexibility and resistance. In wound healing, collagen and proteoglycans repair and remodel this connective tissue. To produce collagen for repair, glucose from the diet is stimulated by Aloe vera and forms glucosamine within the fibroblast. Then, in the presence of zinc and vitamin C, glucosamine forms procollagen. In addition, procollagen can be formed directly from external amino acids. Next, Aloe pushes the fibroblast to convert the secreted procollagen to collagen. The glucosamine and procollagen form the "core protein" as a frame for connective tissue. Also, they form hyaluronic acid as a frame for "link" proteins are essential components for connective tissue. In addition, this connective tissue can double and triple if the necessary sugars and amino acids are stimulated by Aloe vera in the fibroblast.
This activity demonstrates how wound healing is enhanced when connective tissue, subjected to mechanical forces and damages, repair themselves by the aloe-fibroblast stimulating influence to make collagen and proteoglycans. Aloe vera acts as a mechanism to promote the active biological agents that heal damaged tissue.
ALOE VERA AND INFLAMMATION
Inflammation is the response of living tissue to a damaging stimulus. It is a defense mechanism against a traumatic insult. On a molecular basis, the inflammatory process involves complex regulators, potentiators and mediators. A uniform response occurs regardless of the nature of the irritant event, though the inflammatory process may act as a double edge sword by also creating a threat to an organism. Inflammation may be acute or chronic. The acute inflammation response to a tissue insult involves the release of vasoactive substances. This increases the permeability of capillaries so that fluid goes into interstitial tissue and produces edema. Then, polymorphonuclear leukocytes (PMN's) move out of the capillaries and are attracted to the injury site by a mediator called leukotrienes. The PMN's increase their metabolism and oxygen consumption as they phagocytize the trauma debris. However, the products resulting from this increased metabolism contain oxygen radicals that attack the membrane lipids and produce further inflammation. If the irritant remains under the skin, chronic inflammatory response occurs. Connective tissue forms around the irritant and, over a long period of time, attempts to push the trauma outside the body. Lysozymes, products of these inflammatory cells, function in a manner to modulate neutrophil (PMN) activity.
Topical steroids are usually applied to block acute and chronic inflammation but their properties also retard wound healing. They decrease edema by reducing capillary permeability, vasodilation and stabilizing lysosomal membranes. Steroids can actually increase the spread of infection by inhibiting connective tissue formation. Aloe vera is also used to inhibit acute inflammation. But, unlike steroids, it stimulates fibroblast growth to improve wound healing and block the spread of infection. This is the miracle of Aloe.
Studies have shown that since only about 1% of steroids can penetrate the stratum corneum of the skin, 99% is unavailable and wasted. Our data has shown that Aloe vera can act as a vehicle for steroids - to improve absorption and act as an efficient carrier. This is a significant economic consideration for Aloe vera.
The complexity of Aloe vera's components makes the study of its anti-inflammatory activity a difficult task. Aloe vera does not have a single mechanism of action. Aloe vera contains amino acids such as phenylalanine and tryptophane that have anti-inflammatory activity. The salicyclic acid in Aloe prevents the biosynthesis of prostaglandins from arachidonic acid. This explains, in part, how Aloe reduces vasodilation and decreases the vascular effects of histamine, serotonin and other mediators of inflammation. Since prostaglandins play an integral role in regulating both inflammation and immune reactions, Aloe vera can affect both of these systems by blocking prostaglandin synthesis. The analgesic effect of Aloe vera is synergistic with aspirin. Since Aloe vera has both stimulatory and inhibitory components. Aloe can modulate both immune and inflammatory reactions. It can act as a stimulator of wound healing and antibody production. Aloe can block prostaglandin and modulate the production of lymphocytes and macrophage derived mediators (lymphokinins) including interleukins and interferons. Besides Aloe's effects on inflammatory and immune reactions, it also acts as a scavenger of free oxygen radicals produced by PMN's. The vitamin C in Aloe that inhibits inflammation picks up oxygen radicals to block the inflammatory process. Vitamin E, a known antioxidant, is also a component of Aloe vera. These biological effects of the orchestra work in collaboration with the conductor (polysaccharide) to produce these valuable therapeutic effects.
ALOE VERA IS A BIOLOGICAL VEHICLE
Compounds that are poorly absorbed through the stratum corneum of the skin need a vehicle to aid them in penetration. Glucocorticoids and vitamin C are not absorbed well and, as a result, most of the material is wasted when applied topically. A vehicle must be found that solubilizes steroids and Vitamin C while at the same time hydrates the stratum corneum. As previously mentioned. Aloe vera's anti-inflammatory, wound healing and analgesic properties make Aloe a "biological vehicle" that helps to nullify the detrimental activity of glucocorticoids but at the same time aids the penetration. Similarly, vitamin C is not readily absorbed by the tissue. However, vitamin C has been shown to help in the synthesis of collagen, since it may counterbalance the collagen breakdown to reduce the development of autoantibodies. In certain diseases, such as rheumatoid arthritis, the levels of vitamin C are low. Our data, thus far, suggests that Aloe vera aids in the absorption of vitamin C and adds to its biological activity. Although all the factors that control the absorption of vitamin C are not known, previous studies show esterifying ascorbic acid increases the availability to tissues so that the therapeutic dose can be reduced. In a similar manner, Aloe vera's activity as a biological vehicle to increase the absorption of vitamin C may be just as possible.
Aloe vera can solubilize water soluble compounds as well as lipid soluble substances. Also, it can hydrate the stratum corneum cell membranes to aid a range of materials in penetrating the skin. The biological activity of Aloe can add and even synergize with many agents in producing therapeutic effects so that we call Aloe vera a "biological vehicle".
Aloe vera contains polysaccharides that act as a conductor to direct biological activities among an orchestra of various molecules. Many agents within Aloe have been isolated, identified and demonstrated to synergize with one another over a large biological spectrum. A standard preparation of Aloe vera with a well-defined unit for each biological activity is necessary for future research. The conductor-orchestra theory opposes the idea that suggests that one molecule in Aloe (a polysaccharide) is responsible for the beneficial effects and that the standardization should be based on that polysaccharide. A greater understanding between the conductor and orchestra is needed to better define how Aloe vera synergizes its many activities. This understanding will change many pharmacologic concepts in the future. The conductor-orchestra concept will be practiced as the central format by which the Aloe industry will operate.
*This research was funded by Aloecorp.
Gelatin (also gelatine, from French gťlatine) is a translucent, colourless, brittle, nearly tasteless solid substance, extracted from the collagen inside animals' connective tissue. It has been commonly used as an emulsifier in food, pharmaceutical, photography, and cosmetic manufacturing. Substances containing gelatin or functioning in a similar way are called gelatinous. Gelatin is an irreversibly hydrolyzed form of collagen. Gelatin is classified as a foodstuff and has E number 441.
Gelatin is a protein produced by partial hydrolysis of collagen extracted from the bones, connective tissues, organs, and some intestines of animals such as the domesticated cattle, and horses. The natural molecular bonds between individual collagen strands are broken down into a form that rearranges more easily. Gelatin melts when heated and solidifies when cooled again. Together with water, it forms a semi-solid colloid gel. Gelatin forms a solution of high viscosity in water, which sets to a gel on cooling, and its chemical composition is, in many respects, closely similar to that of its parent collagen.  Gelatin solutions show viscoelastic flow and streaming birefringence. If gelatin is put into contact with cold water, some of the material dissolves. The solubility of the gelatin is determined by the method of manufacture. Typically, gelatin can be dispersed in a relatively concentrated acid. Such dispersions are stable for 10-15 days with little or no chemical changes and are suitable for coating purposes or for extrusion into a precipitating bath. Gelatin is also soluble in most polar solvents. Gelatin gels exist over only a small temperature range, the upper limit being the melting point of the gel, which depends on gelatin grade and concentration and the lower limit, the ice point at which ice crystallizes. The mechanical properties are very sensitive to temperature variations, previous thermal history of the gel, and time. The viscosity of the gelatin/water mixture increases with concentration and when kept cool (≈40įF).