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Re: MS and you as my best friend
 

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happyhealthygal Views: 4,570
Published: 13 years ago
 
This is a reply to # 1,218,741

Re: MS and you as my best friend


What's misleading or erroneous? I didn't say anything about CS in that post - I said what I would do. If I wanted to try a natural remedy for MS, I would take oleander over CS because there's far more "rational basis" behind taking oleander for MS than there is behind taking CS.
rational basis for taking oleander for MS:

- oleandrin + inhibition of NF-kB
Oleandrin Suppresses Activation of Nuclear Transcriiption Factor-kB, Activator
Protein-1, and c-Jun NH2-Terminal Kinase:
http://cancerres.aacrjournals.org/cgi/content/full/60/14/3838


Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor

http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1160519



- Why inhibiting NF-kB MAY help for MS:

http://www.nature.com/ni/journal/v7/n9/abs/ni1372.html


http://hypography.com/news/life-sciences/35250.html
(popular press article on the study)

Here's a good list of other substances that, to varying degrees, inhibit NF-kB:
http://people.bu.edu/gilmore/nf-kb/inhibitors/index.html

pilot study on LA:
http://msj.sagepub.com/cgi/content/abstract/11/2/159


I don't know if oleander will be helpful (nobody really does), but I suspect that the chances are a lot higher that oleander will be helpful than that CS will (I have not yet heard a plausible mechanism for the utility of CS for MS or autoimmune disease in general, although if someone has one, I will be delighted to hear it).

What does "supporting the immune system" even mean? HOW does CS support the immune system? "immune support" and "immune boost" are two buzzword terms that mean absolutely nothing.
 

 
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