as for me i did the 18 day cleanse in september and have been doing the once a week maintenance since then, until dec... in dec. the maintenance dose began giving me loose stools so i figured that i didn't have anything left to kill as it was kind of washing through me without any dieoff symptoms... so i began late dec. to do the maintenance once every two weeks and i've done that once now and ready for another... it was much better, no runs, and some dieoff... in addition i've done the coQ10 4 times... taking 3,000 mg. at a time, and the last one i did was in late november... dr. clark says the coQ10 is supposed to kill off the hard to reach Ascaris and Tapeworm casts in the bone and brain... i figure i will do this probably every 2-3 mos. in the future... you are supposed to empty the capsules into a Tblsp. of honey and take it down... it doesn't taste too bad in the honey and i've had absolutely no symptoms from any one of the 4 times i've done this... hope this helps!