I too have bought the higher doses and cut them down. Cutler advises starting out with small dosages and work your way up. DMSA is supposed to be hard on the liver too, so be careful. I'm bringing on the ALA after 2-3 mos of just DMSA to lower the body/organ/blood pool of Hg first. This all providing all Amalgams have been removed, otherwise you'll get a steady supply of poison metals to keep you sick as long as they are in.