good discussion ::: here is an article from the Cuban Ozone people regarding oxidative stress and ozone:::
SECTION: OZONE IN MEDICINE
Medical applications of ozone:
Oxidative stress diagnosis in ozone therapy.
Hernández F. (Cuba)
Ozone therapy is closely related with the oxidative stress concept since one of its main properties is to produce, paradoxically, an antioxidant effect by means of transient, regulated, exogenous and repeated oxidative stress.
This ozone therapy property is able to regulate the endogenous oxidative stress established in different diseases. Therefore, the diagnosis or measurement of oxidative stress level is relevant for ozone therapy because allows treatment individualization and to know therapy effectiveness.
One of the main reasons limiting the approval of ozone therapy by orthodox medicine has been the lack of controls. Competent control systems to assess the benefits and risks of systemic ozone therapy are not always used and in such case the treatment is based on anecdotal reports. A real diagnosis of the oxidative stress should be used as control system in systemic ozone therapy. A system for oxidative stress diagnosis has been developed in the Ozone Research Center of Cuba, which has been successfully evaluated in different pathologic conditions before and after ozone therapy cycles of treatment.
Eight blood biochemical parameters are determined and their results computerized in software, which assess a redox index giving five grades of oxidative stress. The grade zero means no oxidative stress, grade 1 indicates slight oxidative stress, grade 2 is moderate oxidative stress, grade 3 is severe oxidative stress, and grade 4 is very severe oxidative stress. The ozone therapist can estimate the ozone concentration to be applied taking into account the grade of oxidative stress the patients have. Those patients in grade 4 it is recommended to treat with antioxidants before systemic ozone treatment, or to apply ozone therapy at a very low concentration and dosage being very cautious.
During the evaluation of our system for oxidative stress diagnosis we found that the majority of patients with different diseases, where oxidative stress was involved, improved their oxidative stress condition after ozone therapy treatment.