As soon as my throat starts to ache in the thyroid area, that's my signal to stop for the week. (Except for transdermal, which we decided on this forum a couple of days ago is only about 6% to 12% bioavailable.)
This week I took 2 drops on Monday, 3 on Tuesday, 3 on Wednesday, throat started to ache, I cut back to 1 on Thursday, throat still aching so I stopped for the rest of the week, will start with 2 on Monday again.
My husband hasn't had the achy throat thing much if at all. He takes 2 - 3 drops a day every day, and stops on the weekends only because I talked him into stopping, because that's what Cayce always recommended. (Cycling).
He is doing really well on just the 2 - 3 drops a day, has lots more energy, generally feels healthier, many symptoms disappeared, etc.
I feel good, too! We both had very mild flu-like symptoms the second week a couple of days.