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Peroxiredoxin 5 Gene Associated with Alopecia Risk
Maniek Views: 2,563
Published: 11 years ago
This is a reply to # 1,677,638

Peroxiredoxin 5 Gene Associated with Alopecia Risk

One thing I don't understand is how Thyroid disorders cause hair loss via DHT. What is the connection between the Thyroid and DHT. I know I probably won't get an answer for this. 

Peroxiredoxin 5 Gene Associated with Alopecia Risk
A recent study (see ref. below) of genes associated with alopecia identified genes involved in Treg and Th-17 development, as well as peroxiredoxin 5 as contributors. As expected, several genes involved in antigen presentation (HLA-DRA, HLA-DQA) were also identified. Th-17 lymphocytes are involved in immune attacks on self tissue, i.e. autoimmune diseases, such as alopecia, in which hair follicles are attacked by the immune system. Tregs control immune attacks on self tissues. Peroxiredoxin is an autoantigen and is produced in elevated amounts around hair follicles attacked in alopecia.


Servus Mariusz




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