I have read a lot on the pineal gland and brain calcification in general, some great books, radio interviews and videos out there. The term "io-synchronicity" is new to me though.
I have also been displacing the halides using monatomic gold and silver away from Iodine supplementation. Grounding the body to the earth's magnetic field can also greatly decrease the toxicity and increase the functionality and absorption of iodine. Keeping the adrenals in balance with the thyroid using multiglandulars and beneficial thyroid supplementation can also help a great deal. I also use my nsPEMF device on my bottle of Lugol's. This might also be the difference I am seeing.
Using the entire regimen, I've experienced very little detox or flu-like symptoms with as much as 200mg daily, not the case with just Iodine alone.