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Re: Frontal Lobe headache again
Mike1953 Views: 6,231
Published: 10 years ago
Status:       RR [Message recommended by a moderator!]
This is a reply to # 1,754,288

Re: Frontal Lobe headache again

Several methods of bromine detox here, I found the half-life times particularly interesting

Treatment of Bromism
The most important element of treatment is cessation of bromide exposure. Additional treatment of bromide toxicity has traditionally involved saline loading (administration of large quantities of sodium chloride in water, typically by vein), which enhances kidney excretion of bromide. The chloride ion from sodium chloride competes with and replaces the bromide ion throughout the body. While the usual half-life of bromide (the time for half the body's complement of bromide to be eliminated) is 12 to 14 days (Horowitz, 1997), a half-life of 65 hours has been calculated with saline loading. Cases failing to respond to saline loading have been successfully treated with mannitol or "loop" diuretics (a type of diuretic, or water-excretion enhancing agent, that acts on a specific part of the kidney), and one report calculated a half-life of 1.65 hours with "diuresis," using the agents mannitol and ethacrynic acid (Horowitz, 1997). Hemodialysis has been used to treat bromism. Calculated bromide half-lives with hemodialysis in different case reports have been 1.78 hours (in a case report from 1951) (Merrill and Weller, 1952), 0.9 hours, and 1.38 hours in a more recent case report (Horowitz, 1997). Hemodialysis led to prompt resolution of focal neurological signs in a patient who failed to respond to saline (sodium chloride solution) (Horowitz, 1997). Patients with a depressed mental status due to bromism, or with bromide levels in excess of 200 mg/dL (25 mmol/L) may not achieve nontoxic levels (without treatment) for almost a month and would require five days of saline loading to achieve levels below 50 mg/dL (6.3 mmol/L), the threshold of what is normally construed as the toxic level (Horowitz, 1997). Therefore, in these cases it may be appropriate to use hemodialysis to remove the bromide ion from the blood rather than relying on the kidney (Horowitz, 1997).


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