I think it is best to stick to the instructions the first time and once you have some experience you may want to modify to suit your own body. The orinithine is to help you sleep, Clark wrote that if you don't take it you may have a miserable night. Clark worked out the timing carefully because the body carries out different functions depending on whether it is day or night. If you dont do the 4 doses of ES some of the stones/sludge may not come out in the purge and become lodged in the folds and turns of the intestine. It is also more likely that some of the gall system stones may stick and cause blockages in the gallbladder or bile tubules. You need as good a purge as possible and you want the relaxing effects of the Mg.