The Fluoroquinolones also known as Quinolones are a class of synthetic broad spectrum Antibiotics . Broad spectrum antibiotics are effective in neutralizing varied types of bacteria of both, gram positive and gram negative type. Nalidixic acid was the first type of Fluoroquinolone used in the treatment of urinary tract infections in 1962. Many types of Fluoroquinolones have been developed since then. A second generation Fluoroquinolone called Ciprofloxacin is often used in the treatment of kidney infection. However, this is not generally recommended as the first choice of antibiotics for kidney infection treatment. It is used if the first line of antibiotics fails and the kidney disease is particularly acute. Amoxicillin can also cause a measles-like itchy rash. This occurs particularly in cases where the patient has had no previous exposure to penicillin like antibiotics.