To get the benefit of the elemental iodine in Lugol's, you need to take the iodine separate from the vit C. You can see what happens to Lugol's if you put some Lugol's in water, check out the color, then add vit C crystals (open a capsule if that's what you have). The tawny color should become clear. You now have all iodide, not the iodine/iodide combo.
The reason I'm saying this is because in the beginning depression was a giant pit for me. I was detoxing psych meds. For me the iodine part of Lugol's made the depression worse, whereas the iodide part made the depression better. I got all iodide by using SSKI (saturated solution of potassium iodide). You could get iodide by combining Lugol's and vit C. Possibly if you do this sometimes to get a break from the iodine part of Lugol's, yet still keep taking Lugol's, you will get some relief from the depression.
Or not. Everybody's different. Just an idea that worked for me :)