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Re: The Dark Side of The Alternative Health Movement: Promoting Ingested Iodine
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Published: 9 years ago
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This is a reply to # 1,945,601

Re: The Dark Side of The Alternative Health Movement: Promoting Ingested Iodine

Those writers are not reliable. Reading their incomplete rhetoric and historic bashing of iodine/iodide AND curezone tends to get old. Each person's therapeutic range of iodine/iodide is different, it all depends on individualistic variables and applicable circumstances. There's too much bias on that site to merit serious rebuttal objectively (here too even), whether they are right or wrong.

Bias can go both ways.  Look at the iodophiles here on Curezone.  You cannot even mention an adverse effect of iodine without them coming down on you until they feel they squashed you.  I mentioned some dangers of iodine such as the adverse effects of of too much iodine on Hashimoto's.

So I would trust the claims of the link I posted over the iodine trolls here on Curezone anytime.  Especially when there are plenty of evidence readily available as to the dangers of iodine in levels much lower than the lowest levels the iodophiles here keep recommending.

So what exactly in their article is unreliable in your view?


Let's see what some of the medical abstracts show as far as toxicity: 

"Presentation, Formulation

           Iodine is available in solid form, in solution, and in 
           tinctures, e.g.
           Povidone iodine antiseptic solution, surgical scrub 7.5%, 
           povidone iodine 200 mg pessaries, povidone antiseptic 
           ointment 100 mg/g.
           Tincture of iodine, USP, contains 2% cent iodine and 2.4% 
           sodium iodide diluted in 50% ethanol.
           Aqueous solutions of iodine are Strong Iodine Solution USP 
           (compound iodine solution, Lugol's solution) containing 5% 
           iodine and 10% potassium iodide, and Iodine Topical Solution 
           (USP) containing 2% iodine and 2.4% potassium iodide. Aqueous 
           Iodine Solution BP contains the same amount of free and 
           combined iodine per ml (130 mg/mL) as does the USP Strong 
           Iodine Solution. (Reynolds, 1993)
           Potassium iodide aqueous cough expectorant.
           Povidone-iodide (Betadine) is an organically bound iodide 
           compound containing 1% iodine in a water soluble base. Other 
           organically bound iodide compounds are undecoylium chloride, 
           diiodo hydroxyquin, tetraglycine hydroperiodide (60% iodine). 
           These organic iodide compounds release iodine slowly and have 
           a toxicity of one fifth of their iodine content (Haddad & 
           Winchester, 1983).
           Povidone iodine antiseptic solution and surgical scrub are in 
           5 litre containers, pessaries, ointment (see 1.7).

    2. SUMMARY

       2.1 Main risks and target organs

           Concentrated iodine is corrosive. Main risks in acute 
           exposure to high iodine concentrations are largely due to the 
           highly corrosive effect of iodine on the entire 
           gastrointestinal tract and resultant shock. If rupture occurs 
           mediastinitis or peritonitis develop.
           Target organs are mucous membranes of pharynx, larynx and 
           oesophagus for the concentrated iodine, and thyroid for the 
           diluted form as a systemic effect. Iodine is not a frequent 
           cause of toxicity in the amounts available in the household.
       2.2 Summary of clinical effects

           Ingestion of iodine may cause corrosive effects such as 
           oedema of the glottis, with asphyxia, aspiration pneumonia, 
           pulmonary oedema and shock, as well as vomiting and bloody 
           diarrhoea. The CNS , cardiovascular and renal toxicity 
           following acute iodine ingestion appear to be due to the 
           corrosive gastroenteritis and resultant shock. Vomiting, 
           hypotension and circulatory collapse may be noted following 
           severe intoxication.
           Eye exposure may result in severe ocular burns.
           Tachycardia, hypotension and circulatory collapse may be due 
           to the ingestion of concentrated corrosive iodine solutions.
           Inhalation of iodine vapour may result in severe pulmonary 
           irritation leading to pulmonary oedema.  Oedema of the 
           glottis and pulmonary oedema have also resulted from oral 
           Headache, dizziness, delirium and stupor may be noted 
           following severe intoxication.
           A severe corrosive oesophagitis and gastroenteritis 
           characterised by vomiting, abdominal pain and diarrhoea may 
           be noted following ingestion. The vomitus is blue if starch 
           is present in the stomach. A metallic taste may be noted.
           Dermal application of strong iodine solutions may result in 
           Chronic ingestion may result in iodism characterised from 
           acne form skin lesions and other skin eruptions.
           Cutaneous absorption may be significant and result in 
           systemic symptoms and death.
           Hypothyroidism, as well as hyperthyroidism, has been 
           Hypersensitivity reactions including angioedema and/ or serum 
           sickness-like reactions may be noted." 

           Iodine preparations should not be taken regularly during 
           pregnancy and lactation.
           Because iodine may cause burns on occluded skin, an iodine-
           treated wound should be covered with a light bandage. As 
           iodine and iodides can affect the thyroid gland, the 
           administration of such preparations may interfere with tests 
           of thyroid functions (Reynolds 1989; McEvoy, 1990).
           Potassium iodide should not be used in adolescent patients 
           because of its potential to induce acne and its effects on 
           the thyroid gland (Bouillon ,1988).
           Iodine or iodides should not be administered to patients with 
           a history of hypersensitivity to such compounds." 

           Iodides diffuse across the placenta. Infant and neonatal 
           death from respiratory distress secondary to goitre has been 
           reported in mothers taking iodides(Parmalee et al., 1940; 
           Galima et al., 1962).
           Chronic topical maternal use of povidone-iodine during 
           pregnancy has been associated with clinical and biochemical 
           hypothyroidism in the infant (Danziger et al., 1987). 
           Exposure to I 131 can damage or ablute the developing thyroid 
           of the human foetus. Hypothyroidism, either congenital or of 
           late onset, has been reported in at least 5 children whose 
           mothers were exposed to I 131 during pregnancy (Shepard, 
 "Main adverse effects

           Endocrine system effects
           Iodine and iodides produce goitre, hypothyroidism as well as 
           hyperthyroidism. These effects have also been reported in 
           infants born to mothers who had taken iodides during 
           pregnancy (Reynolds, 1989).
           Side effects of iodine given for radioprotection
           In iodine-induced goitre and iodine-induced hypothyroidism, 
           special risk groups are foetus and neonates. Iodine-induced 
           hyperthyroidism special risk group are people living in 
           iodine deficient areas and people with a history of 
           hyperthyroidism, (Bouillon, 1988). Extrathyroidal side 
           effects are gastrointestinal complaints (nausea, pain), taste 
           abnormalities, cutaneous and mucous membrane such as 
           irritation, rash, oedema (including face and glottis), 
           allergic-like reactions such as fever, eosinophilia, serum-
           sickness-like symptoms, vasculitis. Special risk groups are 
           patients with hypocomplementic vasculitis, (Bouillon, 1988).
           Allergic effects
           Whether iodine is administered topically or systematically, 
           iodine and iodides can give rise to allergic reactions: 
           urticaria, angioedema, cutaneous haemorrhage or purpuras, 
           fever, arthralgia, lymphadenopathy and eosinophile, acne-form 
           or severe eruptions.
           Iodism effects
           A mild toxic syndrome called iodism results from repeated 
           administration of small amount of iodine. Iodism is 
           characterised by hyper-salivation, coryza, sneezing, 
           conjunctivitis, headache, laryngitis, bronchitis, stomatitis, 
           parotitis, enlargement of the submaxillary glands, skin 
           rashes and gastric upsets, (Reynolds, 1989, Gosselin et al, 
           1984). In rare cases jaundice, bleeding from mucous membranes 
           and bronchospasm may occur. Inflammatory states may be 
           aggravated by these adverse reactions, (Bouillon, 1988).
           Gastrointestinal effects
           Acute effects due to ingestion of iodine are mainly due to 
           its corrosive effects or action which arises at least in part 

           from oxidizing potential of this element on the 
           gastrointestinal tract. Symptoms include a metallic taste, 
           vomiting, abdominal pain, and diarrhoea. Oesophageal 
           stricture may occur if the patient survives the acute stage, 
           (Reynolds, 1989; Gosselin et al., 1984).
           Cardiovascular and respiratory effects
           Death may occur due to circulatory failure, oedema of the 
           glottis resulting in asphyxia, aspiration pneumonia, or 
           pulmonary oedema, (Reynolds, 1989, Sittig 1981).
           Kidney effect
           Anuria may occur 1 to 3 days after exposure, (Reynolds, 
 "Acute poisoning 

           9.1.1 Ingestion

                 Ingestion of iodine may cause corrosive effects such as 
                 oedema of the glottis, with asphyxia, aspiration 
                 pneumonia, pulmonary oedema and shock, vomiting and 
                 bloody diarrhoea.  The CNS, cardiovascular and renal 
                 toxicity following acute iodine ingestion appear to be 
                 due to the corrosive gastroenteritis and resultant 
                 shock.  Vomiting, hypotension and circulatory collapse 
                 may be noted following severe intoxication.

           9.1.2 Inhalation 

                 Inhalation of iodine vapour is very irritating to 
                 mucous membranes. Headache, dizziness, delirium, 
                 collapse and stupor, death due to circulatory collapse, 
                 asphyxia from oedema of glottis, aspiration pneumonia 
                 or pulmonary oedema has been reported. Occasionally 
                 haemorrhagic nephritis may occur within 1 to 3 days, 
                 oesophageal and pyloric stenosis have been reported, 
                 (Gosselin et al., 1984).
           9.1.3 Skin exposure 

                 Skin contact with iodine may give rise to 
                 hypersensitivity reaction, fever and skin eruption. 
                 Death following skin contact covering one third of body 
                 surface is reported to have occurred, (Gosselin et al., 

           9.1.4 Eye contact 

                 Iodine vapour causes irritation and lachrymation in 
                 human eyes, (Grant, 1974).

           9.1.5 Parenteral exposure 

                 Injection of iodine compounds may cause sudden fatal 
                 collapse (anaphylaxis) as a result of hypersensitivity. 
                 Symptoms are dyspnea, cyanosis, fall of blood pressure, 
                 unconsciousness and convulsions, (Dreisbach & 
                 Robertson, 1987).

           9.1.6 Other 

                 No data available.

       9.2 Chronic poisoning 

           9.2.1 Ingestion 

                 Repeated administration of small amounts of iodine may 
                 result in a mild toxic syndrome called "iodism". It is 
                 characterised by hyper-salivation, coryza, sneezing, 
                 conjunctivitis, stomatitis, parotitis, enlargement of 
                 the submaxillary glands, and skin rashes (Barker & 
                 Wood, 1940; Ehrich & Seifter, 1949).
                 Hypotension, tachycardia, cyanosis and signs of shock 
                 are frequent symptoms of iodine ingestion. (Gosselin et 
                 al., 1984).
                 Iodated glycerol used as a mucolytic expectorant in the 
                 treatment of respiratory disorders inhibited the 
                 biosynthesis of thyroid hormone and induced 
                 hypothyroidism (Drinka & Nolten, 1988; Gommolin, 1987).
                 Amiodarone, an iodine rich drug widely used in the 
                 treatment of tachyarrhythmias, represents one of the 
                 most common sources of iodine-induced thyrotoxicosis 
                 (Martino et al., 1987; Regouby et al., 1985).
                 Tablets of seaweed, sold over the counter, is one of 
                 the less common sources of iodine-induced 
                 hyperthyroidism (Shilo & Hirsch, 1990).

           9.2.2 Inhalation 

                 No data available.

           9.2.3 Skin exposure 

                  Intact skin
                 Irritant contact dermatitis caused by povidone-iodine 
                 has been reported, (Okano, 1989). Liberal application 
                 of the tincture or povidone-iodine to the skin resulted 
                 in significant plasma and urine iodine levels and may 
                 cause systemic iodine toxicity (Luckhardt et al., 1920; 
                 Smerdely et al., 1989; Pyati et al., 1977; Chabrolle & 
                 Rossier, 1978; Coakley et al., 1989; L'Allemand et al., 
                 1987; Dantzigen et al., 1987; Schoenberger & Grim, 
                  Injured skin
                 Continuous postoperative wound irrigation with 
                 povidone-iodine resulted in death of a patient. Toxic 
                 manifestations of systemic iodine absorption appeared 
                 to cause the death, (D'Auria et al., 1990; Glick et 
                 al., 1985).
                 Application of povidone-iodine on skin burns may cause 
                 systemic iodine toxicity (Lavelle et al., 1975; Peitsch 
                 & Meakins, 1976).

           9.2.4 Eye contact 

                 Iodine-containing eye drops caused hyperthyroidism 
                 (Geisthoevel, 1984).
           9.2.5 Parenteral exposure 

                 Iodine-containing contrast media may cause 
                 hyperthyroidism; the most frequent thyroid disorders, 
                 usually of a temporary nature, occur after choledochal 
                 contrast media (Steidle, 1989). In premature infants 
                 they cause hypothyroidism (L'Allemand et al., 1987).

           9.2.6 Other 

                 No data available.

       9.3 Course, prognosis, cause of death 

           If the patient survives 48 hours after the ingestion of 
           iodine, recovery is likely, although stricture of the 
           oesophagus or pyloric sphincter may be a complication, 
           (Dreisbach & Robertson 1987). It is probable that the 
           pathological changes recorded in fatal cases of iodine 
           poisoning and attributed to the systemic effects of iodine 

           are largely the result of shock due to massive loss of fluid 
           from the gastrointestinal tract and tissue hypoxia (Gilman et 

       9.4 Systematic description of clinical effects 

           9.4.1 Cardiovascular 

                 Cardiovascular effects are not due directly to iodine 
                 or iodide. Hypotension, tachycardia circulatory 
                 collapse may occur secondary to corrosive 
                 gastroenteritis due to ingestion of highly concentrated 
                 iodine solutions. In acute iodine inhalation, 
                 hypotension and tachycardia have been reported, 
                 (Gosselin et al., 1984).

           9.4.2 Respiratory 

                 Inhalation of fumes leads to irritation of mucous 
                 membranes of the respiratory tract, which may result in 
                 asphyxia. Oedema of the glottis from ingestion was 
                 reported in early literature as a frequently mentioned 
                 cause of death, (Finkelstein & Jacobi, 1937).
                 Pulmonary oedema and tachypnoea have been reported 
                 following ingestion of an unspecified large quantity of 
                 Lugol's solution, (Dyck et al., 1979).

           9.4.3 Neurological 

        Central nervous system (CNS) 

                         Headache, dizziness and delirium have been 
                         reported in severe intoxications.  Altered 
                         sensorium (agitation, confusion, 
                         hallucinations) have occurred in association 
                         with elevated serum iodine concentrations, 
                         (Alvarez, 1979; Gosselin et al., 1984).
                         Continued administration of iodine may lead to 
                         mental depression, nervousness and insomnia 
                         (Reynolds, 1989).

        Peripheral nervous system 

                         No data available.

        Autonomic nervous system 

                         No data available.

        Skeletal and smooth muscle 

                         No data available.

           9.4.4 Gastrointestinal 

                 Excessive ingestion of iodine solutions can lead to 
                 gastrointestinal irritation, vomiting and ulceration at 
                 various levels of the upper gastrointestinal tract. 
                 Late oesophageal and pyloric stenosis have been 
                 reported, (Gosselin et al., 1984).
                 If the stomach contains starch the emesis is coloured 

           9.4.5 Hepatic 

                 Elevated serum transaminases and bilirubin 
                 concentrations have been reported occasionally in 
                 patients with elevated serum iodine concentrations, 
                 (Lavelle et al., 1975; Peitsch & Meakins, 1976).

           9.4.6 Urinary 


                         Poisoning is manifested by serum creatine and 
                         levels up to 3.5 mg/dL (309 mmol/L) has been 
                         reported, (Dela Cruz et al., 1987). The renal 
                         lesions, which sometimes resemble acute 
                         tubularnecrosis, may be exacerbated by 
                         haemolytic anaemia, (Gosselin et al., 1984).
                         Nephrotoxicity by iodine contrast media is 
                         reported by  Cacoub et al., (1987).


                         No data available.

           9.4.7 Endocrine and reproductive systems 

                 Transient hypothyroidism characterised by elevated 
                 urinary iodide concentrations, elevated serum iodine 
                 concentrations, elevated TSH concentrations, and low T4 
                 concentrations have been demonstrated in povidone-
                 iodine exposed mothers and their infants (L'Allemand et 
                 al., 1987).
                 Iodine induced thyrotoxicosis is a condition that may 
                 develop in older patients with long-standing iodine 
                 deficiencies who receive high doses of iodine 
                 (Kobberling et al., 1985; Fradkin, 1983; Klein & Levey, 
                 Iodine containing drugs caused thyrotoxic crisis 
                 (Mackenroth, 1990).
                 Excessive iodine intake can cause thyroid autoimmunity 
                 in endemic goitre, (Boyages et al., 1989).
                 Organically bound iodine in the form of iodinated 
                 glycerol used as a mucolytic expectorant can inhibit 
                 the biosynthesis of thyroid hormone and induce 
                 hypothyroidism, (Drinka & Nolten, 1988).
                 Hypothyroidism has also been described in neonates 
                 treated with topical povidone-iodine (Cosman et al., 
                 1988). Topical iodine containing antiseptics may induce 
                 hypothyroidism in very-low-birthweight infants, 
                 (Smerdely et al., 1989). Multiple applications of 
                 povidone iodine in pregnancy, and lactation caused 
                 transient congenital hypothyroidism in a 6 week old 
                 girl, (Danziger et al., 1987).
                 Iodine in contrast agents and skin disinfectants is the 
                 major cause for hypothyroidism in premature infants 
                 during intensive care, (L'Allemand et al., 1987).
                 Iodated glycerol, an organic form of iodine, prescribed 
                 as a mucolytic-expectorant induced a mild 
                 hypothyroidism in a patient with a previous history of 
                 severe potassium iodide-induced hypothyroidism.
                 Amiodarone, an iodine-rich drug widely used in the 
                 treatment of tachyarrhythmias, represents one of the 
                 most common sources of iodine-induced thyrotoxicosis. 
                 It developed not only in patients with underlying 
                 thyroid disorders, but also in subjects with apparently 
                 normal thyroid gland. Thyrotoxicosis occurred either 
                 during treatment with or at various intervals after 
                 withdrawal of amiodarone. Classical symptoms were often 
                 lacking, the main clinical feature being a worsening of 
                 cardiac disorders, (Martino et al., 1987).
                 Tablets of seaweed, sold over the counter, is a real 
                 source of iodine. A 72-year-old female developed 
                 hyperthyroidism while ingesting these tablets. After 
                 stopping, the symptoms of hypothyroidism disappeared, 
                 (Shilo & Hirsch, 1990).
                 Continuous povidone-iodine irrigation caused iodine 
                 toxicity with symptoms of metabolic acidosis, changes 
                 in mental status and the patient died (Glick et al., 
                 Administration of iodine containing eye-drops used as a 
                 cataract treatment caused hyperthyroidism (Geisthoevel, 

           9.4.8 Dermatological 

                 A case of fatal dermatitis following the use of a 2.5% 
                 solution of resublimated iodine in pure industrial 
                 alcohol before a surgical operation has been reported. 
                 The reaction was thought to be due to idiosyncrasy to 
                 iodine. Skin disinfection with iodine has caused goitre 
                 and hypothyroidism in 5 of 30 newborns under intensive 
                 care (Bouillon, 1988).
                 Prolonged exposure to tincture of iodine can induce 
                 superficial necrosis. At least one death has been 
                 reported consequent to extensive skin involvement. 
                 Solutions of iodine applied to the skin should not be 
                 covered with occlusive dressings.
                 Topical application of povidone-iodine on burn patients 
                 may lead to increased iodine/iodide absorption (Lavelle 
                 et al., 1975) and the development of a metabolic 
                 acidosis, renal failure and an altered mental status 
                 although a cause and effect relationship has not been 
                 definitely established.
                 The older literature reports systemic symptoms which 
                 occurred immediately to 24 hours later, rarely 
                 following cutaneous application of one-half to one 
                 normal strength iodine tincture. Symptoms included 
                 fever, diarrhoea, pain, headache and delirium. Skin 
                 eruptions included urticaria to erythema to exfoliative 
                 dermatitis. Mortality was 47% in those 15 cases 
                 reported (Seymour, 1937).
                 Repeated applications of iodophors may cause contact 
                 dermatitis. Allergic reactions occur 12 to 20 hours 
                 after application (Harvey, 1985; Kudo et al., 1988).

           9.4.9 Eye, ear, nose, throat: local effects 

                 Exposure to iodine vapour may cause burning in the 
                 eyes, blepharitis, and severe ocular burns (Finkelstein 
                 & Jacobi, 1937).
                 Iodine vapour may cause rhinitis.
                 Stomatitis and pharyngitis may result from exposure to 
                 iodine vapour or solutions and mucous membranes are 
                 coloured brown. (Finkelstein & Jacobi, 1937).

           9.4.10 Haematological 

                  Neutropenia has been reported in association with 
                  elevated serum iodine concentrations, (Alvarez, 1979).
                  Thrombotic thrombocytopenic purpura has been observed 
                  after repeated administration of small amounts of 
                  iodine, (Ehrich & Seifter, 1949)
                  Haemolysis has also been reported (Dyck et al., 1979).

           9.4.11 Immunological 

                  Reactions to iodine may occur acutely or after chronic 
                  use and may be characterised by coryza, headache, 
                  salivary gland pain, conjunctivitis, fever or skin 
                  reactions (urticaria, acneform, eruptions, erythema, 
                  bullous, ioderma). Oral and intravenous iodine 
                  containing radio-contrast media (e.g Telopaque (R); 
                  I125, I131) may cause iodine hypersensitivity reaction 
                  as well as anaphylactic type reactions, (Crocker & 
                  Vadam, 1963).

           9.4.12 Metabolic 

         Acid-base disturbances

                           Metabolic acidosis may be associated with 
                           iodine toxicity. There is an increased anion 
                           gap due to elevated serum lactate levels (47 
                           micromol/L) (Dyck et al., 1979; Dela Cruz et 
                           al., 1987)

         Fluid and electrolyte disturbances 

                           Elevated serum sodium (hypernatraemia) (156 
                           mEq/L) has been reported (Dela Cruz et al., 
                           Hyperchloremia (127 mEq/L) has also been 
                           reported but probably represents a spurious 
                           elevation due to interference in the assay by 
                           iodine (Dela Cruz et al., 1987).
                           Elevations in calculated osmolarity (340 in 
                           Osm/L) have also been reported (Dela Cruz et 
                           al., 1987).


                           No data available.

           9.4.13 Allergic reactions 

                  Intolerance to iodised X-ray contrast media may cause 
                  reactions consisting of fever, chills, malaise, nausea 
                  and vomiting, skin rash, diarrhoea and even 
                  hypotension. These may be classified as idiosyncratic. 
                  In patients with a history of idiosyncratic reaction 
                  premedication with corticoids and histamines is 

                  indicated or non-ionic contrast reagents should be 
                  used,(Soyer & Levesque, 1990). After interleukin-2 
                  administration an increased incidence of 
                  hypersensitivity to iodine was observed, (Zukiwski et 
                  al., 1990).
                  Hypersensitivity reactions were reported in 14 cases, 
                  secondary to the application of iodine-alcohol 
                  solutions to the skin. Symptoms reported were fever 
                  and generalised skin eruption of varying types. 
                  Despite the wide use of tincture of iodine the 
                  incidence of systemic reactions is low (Seymour, 

           9.4.14 Other clinical effects 

                  No data available.

           9.4.15 Special risks 

                  Maternal ingestion of iodine containing substances 
                  during pregnancy can cause (transient) primary 
                  hypothyroidism in the newborn, (Coakley et al., 1989).
                  Exposure to iodine and radioactive iodine in pregnancy 
                  may lead to permanent hypothyroidism or goitre in the 
                  newborn. Such goitres may become very large and even 
                  create problems during delivery or mechanical 
                  compression during early postnatal life (Bouillon, 
                   Breast feeding
                  Similar warnings to those given for pregnancy against 
                  the use of iodine or iodine-containing drugs applies 
                  during lactation since iodine is actively secreted in 
                  milk, (Bouillon, 1988)."  

        11.1 Case reports from literature 

             Case 1
             Continuous irrigation with povidone-iodine in a 34-month-
             old patient with mediastinitis was associated with iodine 
             toxicity, resulting in fatalities, (Glick et al., 1985). It 
             is suggested that povidone-iodine continuous irrigation of 
             the mediastinum be a contraindication.
             Case 2
             A 63-year-old woman with a suppurative mediastinitis, 
             treated with continuous Polyvinyl-pyrrolidone-iodine (PI) 
             irrigation developed an acute oliguric renal failure due to 
             systemic toxicity of PI. The withdrawal of PI was followed 
             by a complete improvement of renal function, (Campistol et 
             al., 1988).
             Case 3
             Two patients with leg ulcers got worse after the 
             application of a compound mixture of sugar and povidone 
             iodine (sugar/PI compound). Patch-tests showed positive 
             reactions to 10% povidone-iodine in water and 5% potassium 
             iodide in water with no response to sugar. They were also 
             tested with sugar/PI compound containing 3% povidone 
             iodine, resulting in another positive reaction. They 
             improved after the application of sugar/PI compound was 
             discontinued, (Kudo et al., 1988).
             Case 4
             A 34-year-old male with burns covering 80% BSA and a 22-
             year-old female with a 45% BSA burn, showed hyperthyroidism 
             induced by topical treatment with 1% povidone-iodine. After 

             topical treatment with povidone-iodine was discontinued 
             circulating thyroid hormones returned to normal values 
             within weeks (Rath and Meissl,1988).
             Case 5
             Fifteen episodes of infection due to Pseudomonas 
             aeruginosa, including peritonitis and other site 
             infections, occurred in nine patients receiving continuous 
             ambulatory peritoneal dialysis over a 27 month period. 
             Occurrence of P. aeruginosa infection was significantly 
             associated with use of povidone-iodine solution to cleanse 
             the catheter site. Local irritation and alteration in skin 
             flora caused by antiseptic solution or low-level 
             contamination of povidone-iodine solution are potential 
             mechanisms of infection (Goetz and Muder, 1989)
             Case 6
             Vaginal douching with polyvinyl pyrrolidone iodine (PVP-I) 
             during pregnancy resulted in maternal iodine overload and 
             increased the iodine content of amniotic fluid. The 
             possible effect of this therapy was evaluated on the 
             thyroid of the fetus by investigating 62 women with a mean 
             duration of amenorrhoea of 20 weeks who solicited 
             controlled abortion. Nineteen of them douched daily with 
             PVP-I for 2 consecutive days before abortion (treated 
             group). The other 43 women were not treated (control 
             group). In both groups the iodine content was determined in 
             the foetal thyroid and in amniotic fluid and maternal urine 
             at the time of abortion. In addition, in the treated group 
             the concentrations of iodine were also determined in 
             amniotic fluid and urine before therapy and in urine after 
             4 days of therapy. There were no differences in the 
             concentrations of iodine in urine and amniotic fluid in the 
             control group and in the treated group before therapy. 
             Iodine content increased more rapidly in the treated group 
             (from 1 to 7.7 micrograms) than in the control group (from 
             1 to 2.5 micrograms) P less than 0.05  (Mahillon et al., 
             Case 7
             Approximately 570,000 newborns were tested for congenital 
             hypothyroidism between May 1977 and December 1986. One 
             hundred and sixty cases of primary hypothyroidism, were 
             later found to be transient. 14 out of the transient cases 
             were due to excessive intake of iodine. In two, this was 
             due to maternal ingestion of iodide during pregnancy and in 
             12 the babies received large amounts of topical iodine 
             antiseptic. Two cases were caused by maternal anti-thyroid 
             antibodies and in eight instances the cause was unknown. 
             The large number of cases due to topical application of 
             iodine antiseptic emphasizes the need for caution when 
             using this substance in neonates (Coakely et al., 1989)."

"Revision Comments:

Supplier's contact details amended. Reissued according to Regulation (EU) No 453/2010.

Revision Date 11-2011

Revision 3

Supersedes date 02-2010

Risk Phrases In Full

R20/21 Harmful by inhalation and in contact with skin.

R11 Highly flammable

NC Not classified.

R23/24/25 Toxic by inhalation, in contact with skin and if swallowed.

R39/23/24/25 Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed.

R50 Very toxic to aquatic organisms.

Hazard Statements In Full

H370 Causes damage to organs <>.

H332 Harmful if inhaled.

H312 Harmful in contact with skin.

H225 Highly flammable liquid and vapour.

H331 Toxic if inhaled.

H301 Toxic if swallowed.

H311 Toxic in contact with skin."



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