Yes, I too have had Acne problems in the past, pretty severe in my late teens, but mostly cleared up now. When I would pick the skin off my lips prematurely it would agitate the skin around my face, usually making the Acne worse. Also, in another post some talked of flaking of the skin in other parts of the face. Alot of the time when I picked/peeled the skin off my lips, flaking would follow in the area between my bottom lip and my chin, and sometimes above my upper lip also. So it possibly is related in some way to other skin issues for some people.