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Re: Desperate! Can't wait for doxycycline
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Published: 11 years ago
This is a reply to # 2,000,685

Re: Desperate! Can't wait for doxycycline

Antibiotics for the treatment of onchocerciasis and other filarial infections.
Hoerauf A, Adjei O, Büttner DW.
SourceDepartment of Helminthology, Bernhard Nocht Institute for Tropical Medicine, Hamburg, Germany.

More effective drugs are needed for the treatment of human filarial diseases and the elimination of these infections as a public health problem. The drugs must either kill or sterilize adult worms. The relevant filariae, Onchocerca volvulus, Wuchereria bancofti and Brugia species, harbor rickettsial endoboacteria of the genus Wolbachia as symbionts. Animal experiments have shown that the elimination of these endobacteria causes inhibition of embryogenesis, and with Onchocerca ochengi a macrofilaricidal effect. Trials with human onchocerciasis patients using doxycydine demonstrated a long-term sterilizing activity, opening up a new strategy for the control of filarial infections. Indications of antiwolbachial therapy against onchocerciasis are discussed.

So, take the Doxy, add Ketoconazole to make the worms reproduce to females and stop the females from producing eggs with the Doxy. All the while diminishing the requirement for the more expensive medication of Ivermectin?

Any thoughts?

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