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Re: Acid or Alkaline? Which pH inhibits Candida overgrowth?
dvjorge Views: 12,398
Published: 11 years ago
This is a reply to # 2,014,385

Re: Acid or Alkaline? Which pH inhibits Candida overgrowth?

Candida Albicans growths in both, alkaline and acid environments.

The difference is yeast cells (monecells) growth better in an acid Ph and germination is favored by an alkaline Ph.

You aren't going to escape of yeast growing no matter if your Ph is acid or alkaline. However, candida albicans germination results in a more virulent and pathogenic form able to penetrate the epithelial cells.

Of both forms, it is better to deal with the yeast than with a mutated form of it. So, it isn't good idea to force your intestinal Ph to a more alkaline state. Anti-acids are listed as a possible cause of intestinal yeast overgrowth.


Mechanism of Candida albicans transformation in response to changes of pH.
Konno N, Ishii M, Nagai A, Watanabe T, Ogasawara A, Mikami T, Matsumoto T.
Department of Microbiology, Tohoku Pharmaceutical University, Sendai, Japan.
Hyphal growth of Candida albicans was observed at neutral condition, whereas the yeast growth was increased below pH 5. Eight out of 12 strains of C. albicans grow in hyphal form at pH 7, and hyphal formation was inhibited in all strains at pH 4. The addition of GMP, an alternative oxidase (AOX) activator, induced the hyphal growth at pH 4. Although C. albicans grew in hyphal form in pH 7, SHAM, an AOX inhibitor, enhanced the yeast proliferation at this pH. The relative expression level of RAS1 mRNA was higher at pH 7 than at pH 4, indicating that the hyphal formation signal was defective under acidic conditions. Based on these findings, we concluded that AOX-RAS1 signal transduction is the main pathway of hyphal formation of C. albicans, and that the signal was controlled by pH condition.


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