A physiological dose is under 30 mgs a day, not anymore than healthy adrenals would produce on their own. I would never recommend just trying 5 or 10 mg's as that can do more damage it appears. It's sort of like an all or nothing proposition. Either a full physiological dose, or nothing. Google "Jeffries safe uses of cortisol". I am gonna be going on that very soon. The problem with AF is that supplementing is just too difficult, and most don't tolerate supplements anyways, if they have a bad stage of AF, as most on here do. If you can find the right supplement mix, by all means try that first!