I never took medication and I try to run from anything to do with Big Pharma.
However, supplements (depending on what you are using) can cause a detox from a number of things.
For example, ALA and chlorella can detox heavy metals, pesticides, etc. and most of those loose toxins will go through your digestive system and/or others avenues of elimination.
It is best to keep your colon clean everyday and esp. during the times when you know you will go through toxin detox.
Hang in there, the discomfort is usually only temporary.