We both started to take Lugol's few month ago before our trip to Hungary and yes we both experienced increase in energy / mood. First few days when we upped the dosage of Lugol's to 50mg/day , we were so high from it - almost like from a drug. Pleasant warm waves through the body... awesome. Then those pronounced effects disappeared. So I can't say that I experience something new from SSKI (I'm also taking same dosage 5g/daily because I've read that cystitis can pass from one partner to other during sex so we both need to clean our bodies from inside). Yes I have good mood and good energy - but it already seems "normal" to me so I can't tell if it's from SSKI or not :) May be I just get used to it - you know people quickly get used to good things and consider it "normal". But I still cough out a lot of mucus while taking SSKI which I believe is a good thing. My girlfriend feels good now but we will continue with 5g KI daily for few weeks to avoid recurrence of symptoms.