Supplementing with Iodine is kind of like intimate, like "sex". All at once or spread it out over the day, depends on the individual. I suggest a slow buildup, gradually, as long as it feels ok, then give it a huge slam dose, then rest for a couple days. A joke ? Perhaps. Perhaps not. That is how nature works. No sense in getting it all done at once, but then again on the other hand, don't go too slowly. Iodine can be an intimate partner in health. Like, if you get behind the wheel of a Lamborghini, do you immediately floor the accelerator pedal ??? Or go slow a bit. Or, like drinking Scotch, do you down five shots at once, or go slowly ? Etc., yada yada yada. Aren't analogies great.