Thanks for the reply. I have done the 1000 mg of Bufferd vit c crystals every hour to find my recommended dose (my nutritionist recommended this). This is how I know that I can only handle 4000 mg a day. I do a 1/2 tsp 3x a day which equals my tolerable dose. I will however try the flush with vit c also. do you recommend doing this often? How many times a week?