13 people have died in Italy after receiving Novartis' flu vaccine FLUAD
The fact that 13 people died short time after receiving flu vaccine is a terrible tragedy.
The Fluad can kill. There is hardly any other explanation for the death of healthy people.
But even worse than this tragedy is the fact that 65 millions doses of Fluad were administered since it was approved in 1997.
"Due to the poor quality of the available evidence, any conclusions regarding the effects of influenza vaccines for people aged 65 years or older cannot be drawn."
"This review looked at evidence from experimental and non-experimental studies carried out over 40 years of influenza vaccination. We included 75 studies."
"The results are mostly based on non-experimental (observational) studies, which are at greater risk of bias, as not many good quality trials were available."
The Cochrane Collaboration have found no evidence that only vaccinating healthcare workers prevents laboratory-proven influenza or its complications. http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD005187.pub4/abstract
Influenza vaccination for healthcare workers who care for people aged 60 or older living in long-term care institutions.
This review does not provide reasonable evidence to support the vaccination of healthcare workers to prevent influenza in those aged 60 years or older resident in LTCIs. High-quality RCTs are required to avoid the risks of bias in methodology and conduct identified by this review and to test further these interventions in combination.
There is no evidence that only vaccinating healthcare workers prevents laboratory-proven influenza or its complications (lower respiratory tract infection, hospitalisation or death due to lower respiratory tract infection) in individuals aged 60 or over in LTCIs and thus no evidence to mandate compulsory vaccination of healthcare workers. Other interventions, such as hand-washing, masks, early detection of influenza with nasal swabs, antivirals, quarantine, restricting visitors and asking healthcare workers with an influenza-like illness not to attend work, might protect individuals over 60 in LTCIs. High-quality randomised controlled trials testing combinations of these interventions are needed.
Vaccines for preventing influenza in healthy adults http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD001269.pub5/abstract
Vaccination shows no appreciable effect on working days lost or hospitalisation.
The preventive effect of parenteral inactivated influenza vaccine on healthy adults is small: at least 40 people would need vaccination to avoid one ILI case (95% confidence interval (CI) 26 to 128) and 71 people would need vaccination to prevent one case of influenza (95% CI 64 to 80).
Vaccines for preventing influenza in healthy children http://onlinelibrary.wiley.com/doi/10.1002/14651858.CD004879.pub4/abstract
Studies funded from public sources were significantly less likely to report conclusions favourable to the vaccines.
The review showed that reliable evidence on influenza vaccines is thin but there is evidence of widespread manipulation of conclusions and spurious notoriety of the studies.
The content and conclusions of this review should be interpreted in the light of this finding.
Influenza vaccines are efficacious in preventing cases of influenza in children older than two years of age, but little evidence is available for children younger than two years of age.
It was surprising to find only one study of inactivated vaccine in children under two years, given current recommendations to vaccinate healthy children from six months of age in the USA, Canada, parts of Europe and Australia.
If immunisation in children is to be recommended as a public health policy, large-scale studies assessing important outcomes, and directly comparing vaccine types are urgently required.
In February 2014, a total of 25 of the 102 crew members of a U.S. Navy minesweeper sought medical care because of influenza-like illness attributed to an influenza A (H3N2) virus antigenically similar to the H3N2 component of the 2013–14 vaccine. Among the crew members, 99% had received influenza vaccination, including 24 of 25 ill persons. Outbreak management included use of an antiviral medication, exclusion of the ill from the ship for 48 hours, disinfection, hand washing, and cough etiquette. No crew member had onset of symptoms >6 days after the first crew member had symptoms.
Influenza Outbreak in a Vaccinated Population — USS Ardent, February 2014 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6342a3.htm
Apparently, vaccine is "effective", as long as you are able to wash your hands frequently, avoid touching your eyes, nose or mouth with unclean hands, and stay far away from those infected..
Once you do introduce virus into your body, vaccinated, or not, it seems like virus cares less on your vaccination status.
Other similar outbreaks:
Earhart KE, Beadle C, Miller LK, et al. Outbreak of influenza in highly vaccinated crew of U.S. Navy ship. Emerg Infect Dis 2001;7:463–5.
Cosby MT, Pimental G, Nevin RL, et al. Outbreak of H3N2 Influenza at a US Military Base in Djibouti during the H1N1 pandemic of 2009. PLoS One 2013;7:e82089.
The best way to get reliable protection from a flu is to have a flu. Those who have had particular flu, can't get the same or even similar virus again the rest of their life.
That is why healthy people don't get flu every year, but every 5-10 years.
One of the possible reasons why Spanish flu was killing young and strong and leaving alive old and weak was because old and weak may have had immunity developed by having a similar flu virus in the past, giving them enough protection to survive.