Dr. Nakao informally researched urine therapy with soldiers under his command in WW2. Years later he and others did scientific studies on it. He says:
First of all, in order to examine this mechanism, we have to consider that the efficacy of urine therapy does not show it to be a medicine. Urine is an information source about the disease in the body or, in other words, it is a copy of the changes occurring in the body.
Due to the following reasons, I believe that when this information in the urine passes through the throat it is analysed by sensors in the throat, and that the human immune system can then be activated to cure the disease. That is to say, signals are given by the brain which may activate the necessary functions for curing the ailment.
(1). Experiments were conducted and it was found that when the urine was induced into the stomach using a catheter, bypassing the throat for a period of one month, no efficacy was observed.
(2). The fact that cancer occurs in the bladder, urinary tract and kidneys proves that the presence of urine inside the body does not have any direct effect on carcinogenic cells. But when the same urine is taken orally and passes through the throat, a decrease in carcinogenic cell growth or the disappearance of cancer has been observed in cancer patients.
(3). Even if urine is not ingested but only gargled, the effects were found to be the same as when it was ingested.
(4). If gargling with water was done just after ingestion of urine no efficacy was observed.
(5). Interferon, one of many bio-active substances found in urine presents a situation analogous to that of auto-urine therapy in that only minute quantities taken orally are necessary to provide the brain with the information it needs to heal the body. In clinical trials, only 100 IU or 1/100,000 of the million international units of interferon given orally had the same effects as 10 million units administered by injections. (Hayashibara Biochemical Labs., Inc Okayama, Japan and Dr Cummins of Amarillo Cell Culture, Amarillo Texas).
Because of the above findings, it can be assumed that sensor cells which can perceive extremely minute changes in the body, could control them if stimulated by the right information from urine. Such cells are found in the oral cavity and throat said Dr Ryoichi Nakao.
Dr Nakao's theory for the stimulation of cytokine production explains further that urine is the source of information for a given disease. When it is placed in the throat, the sensor cells detect this information, passing it to the brain. In its turn, the brain triggers the cytokine production gland which provides regulation for the immune system. From the brain, interleukin X, together with other enzymes, cause cytokines to be produced and thus effect a recovery from illness. Propolis, a substance extracted from honeycombs has been known since ancient times to have anti-bacterial and anti-tumorial effects. Urine mixed with propolis, enhances its efficacy against cancer, hepatitis and other diseases according to research in Japan. (Dr Ryoichi Nakao).
Immune system regulating factors were originally known as interleukin (IL). Later, interleukins, colony stimulating factors, interferon and other similar substances were generally called cytokines since they are secreted by cells, and affect other cells in one way or the other. (Dr Ryoichi Nakao).