Hello. I also have adrenal fatigue and used to have gallbladder sludge (see my post from 3/16 entitled 'gallbladder sludge'). I used the herbs from Sensible Health and thought they did help. And I don't think there is any concern about these herbs being a problem with adrenal fatigue. But I do think that Liver Flushes are a problem with adrenal fatigue-it's just too hard on one's system. Take a look at my post and you will find some ideas about how to address this problem. Good luck to you! Gigi