There are some nutrients that must be replenished on a daily basis because they wash out of the body, like Iodine. Other nutrients can/will store up in your system and stay until you need them, like selenium. If you take too much of the ones that build up in your system, you develop toxicity symptoms. Taking too much of something that is good in small quantities will poison your system in large quantities. Taking too much of something that is getting washed out daily by the kidneys will put stress on them, especially if they are chelating agents and you have a lot for them to chelate, as there will be a lot of washing to do. Otherwise, it usually doesn't hurt to take a lot of them. I've heard it is possible to drown in a teaspoon of water, but I tend to err on the side of thinking that if a little bit is good, then a whole lot would have to be better. I've made so many suds it took a long time to clean them up when I used too much of the wrong kind of soap. That is probably how a lot of other people operate too.