Like everyone else, I have tried just about everything trying to regain my health from 5 years of systemic candida. So, I am giving Three-Lac a try. I am using only half the amount they suggest and have the most severe rectal itching (sorry to be so graphic) ever. I have contacted the distributor and they said this usually subsides after a couple of weeks - after three months it is still as bad as ever. I have been bolstering up on the vitamin C, milk thistle, multi, and upping the water intake. Looks like I have just a horrible reaction to probiotics - any insight? I know this is a die off situation but what happens when it NEVER stops? Does Five-Lac seem to work? Super tired of being tired..... Thanks.