I think I've made a couple of big mistakes to my health that I think contribute to an impaired metabolism. I took anti- depressants for 13 years (Prozac & Zoloft) I believe these did significant damage to my body, however I quit them cold turkey about 12 years ago and I feel much better without them. Also, I had a tubal ligation and I feel that has changed my natural hormones.
But there is something else. My sister (who can afford medical care) tested positive for the MTHFR gene mutation and in fact has both A1298C & C677T which means both of our parents passed it on and the likely hood that I have the same mutation is very high.