I definitely would not use the Neem straight on without mixing it with a little toothpaste first. There is something very special about the mint. And the texture of the toothpaste tends to hold it in place. Oil by itself is so runny and if it spreads in the eyes there is nothing you can do but endure the pain for a while. I think a little hurt is good, but a lot of hurt is miserable. So I try to stay right on the edge to maximize the speed of healing.