Experimental Work on the Treatment of Strongyloides in Rate.
Foreign Title : Recherches expérimentales sur le traitement de la strongyloidose murine.
Author(s) : ARREZA-GUZMAN, A.
Journal article : Annales de Parasitologie Humaine et Comparee 1937 Vol.15 No.2 pp.125-145 pp. ref.30
Abstract : Rats infected with " Strongyloides ratti" were treated with pyre-thrines, gentian violet, thymol, oil of chenopodium, tetrachlorethylene, and glycerine, and the worms were not killed off though the rats were.
Even when these drugs killed the host, the intestine still contained large numbers of living strongyloides; the cure is still to seek. Again when there were added to 5 cc. of Ringer's solution washed strongyloides and two drops of a 1 in 1, 000 alcoholic solution of thymol or two drops of oil of chenopodium the lethal action was definite, with tetrachlorethylene this was doubtful and with methyl violet and the pyrethrines there was none. Here, it is claimed, is a simple and exact method for testing the efficacy of new drugs. [This important claim, it is here suggested, is not good. As these very experiments show, results from in vitro tests cannot be transferred to conditions in vivo; thus thymol after absorption into man's body is excreted as a glycuronate; it has been changed in the body and the analogy with some other drugs suggests that it is some substance which comes into being during such change which is the true anthelmintic. Nor can in vivo experiment in one animal be taken unhesitatingly as evidence for what happens in another, since such an anthelmintic substance as may be formed by physiologicp-chemical changes in one animal will not necessarily be formed in another; for if the physiological chemistry of all animals were alike there would not be that marked restriction of particular parasites to particular hosts which there is. The results of anthelmintic experiments, whether of those in vitro or of those in vivo on animals other than man, may be taken only with hesitation as being certainly true for man.] C. L..