In a 2016 study measuring the effect of water and fat-soluble vitamins on candida growth in parenteral nutrition formulas, “…the C. albicans increased rapidly in the PN solution supplemented with the SVs or biotin, but increased slowly with each of the other water-soluble vitamins.” Of course this doesn’t replicate internal conditions but it does show that candida can use biotin to fuel its fungal growth.
Several studies in the mid-1940s to the late 1950s showed that of almost 100 Candida strains tested, almost all of the strains required biotin for growth. Their conclusion, “It is evident that biotin is the principal vitamin requirement of C. albicans.”
A 2013 study on biotin and candida showed, “Biotin is required for cell growth and fatty acid metabolism because it is used as a cofactor for carboxylases such as acetyl-CoA carboxylase, and pyruvate carboxylase. In addition, we have discovered that biotin is used to modify histones in C. albicans.”
This 2011 study shows that “Biotin is required by a variety of yeasts, fungi and bacteria, not only for growth but also for metabolite production.” It appears that biotin is necessary for many microbes, including candida. In fact, candida produces biotin and the higher the availability of sugar, the greater the production of biotin. This may be a link in the association between fungal candida growth in diabetics.