The U.S FDA approved the drug Stelara which contains Ustekinumab as an active ingredient and the inactive ingredients L-histidine, L-histidine monohydrochloride monohydrate, Polysorbate 80, and sucrose. Ustekinumab is a human IgG1κ monoclonal antibody against the p40 subunit of the IL-12 and IL-23 cytokines. Using DNA recombinant technology, Ustekinumab is produced in a well-characterized cell line and purified using standard bioprocessing technology. This medicine comes in 45 mg/0.5 ml or 90 mg/ml and 130 mg/26 ml (5 mg/ml) to administer intravenously and subcutaneously. This medicine treats moderate to severe plaque psoriasis, phototherapy or systemic therapy candidates, active psoriatic arthritis, and moderately to severely active Crohn's disease.
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