I have always tried to take at least 3 a day. I have gotten good results with this. (Passed about 3 feet of mucoid plaque a day). Of course I've been quite ill at this dose, now going on my 4th month. I have been to ill to work, so that hasn't been an issue for me. I figure I'm sick anyway, and the quicker I get rid of the yeast the sooner I'll be able to feel decent again.