I don't know much about over the counter creams or prescription drugs for herpes, but I do know that neither of them will cure the problem. I have a friend with genital herpes and I suggested to her that she use Kombucha Tea. Drink the tea regularly and cut a piece of the culture and place it on the breakout. After a day or two it will disappear and there won't be any pain or itching. She tried it and it worked beautifully. She had one more breakout after that but caught it as soon as she felt it coming on and used the culture and by the end of the day it was gone. She has had no more breakouts.
I used to get cold sores every so often, which is also Herpes Simplex, I used the culture on it and the pain went away immediately and healed within a day and has never returned.
If you don't know what Kombucha Tea is, do a Google search and read the first few links. They will tell you everything you need to know. Then you may want to get on the Original_Kombucha group through Yahoo, they are very helpful and will answer any questions you have.