I am not taking probiotics right now. I might start back up in a little while, but for now I'm just taking the liver stuff and the herbal Antibiotic stuff. For SAMe, I got the Jarrow's tablet form. I don't know if they come in powder form. I think they need to be in tablet form so they can bypass the stomach for better absorption in the intestines. If SAMe does work for you, please let me know. I would have taken it longer but I just can't do tablets.