Yes, I used both and not sure what is better but from the start I was alot better. What I did was the first month I did three lac. The second month I order three lac and primal defence and alternated it and some days took both. The third month or so to the present I used just three lac. Since all my allergies went away within the first month cant say which is better but i can tell you that since all your trying to do is introduce friendly bacteria back into your system and both products are for that purpose it doesnt hurt to do both. Maybe thats what made me beat this condition I had for ten years. If you havnt read any of my comments you might want to. I am a believer that probiotics do work.